Human multipotent mesenchymal stromal cells use galectin-1 to inhibit immune effector cells

Human multipotent mesenchymal stromal cells (MSCs) suppress proliferation and alloreactivity of T cells. Several signaling molecules and enzymes contribute to this effect. We focused on carbohydrate-protein interactions and investigated whether lectins are involved in immune modulation by MSC. Gene...

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Veröffentlicht in:	Blood 2010-11, Vol.116 (19), p.3770-3779
Hauptverfasser:	Gieseke, Friederike, Böhringer, Judith, Bussolari, Rita, Dominici, Massimo, Handgretinger, Rupert, Müller, Ingo
Format:	Artikel
Sprache:	eng
Schlagworte:	Autoimmune diseases Base Sequence Biological and medical sciences Blood CD4 antigen CD4-Positive T-Lymphocytes - cytology CD4-Positive T-Lymphocytes - immunology CD8 antigen CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - immunology Cell culture Cell Proliferation Cell surface Cells, Cultured Coculture Techniques Cytokines - metabolism DNA Primers - genetics Effector cells Enzymes Galectin 1 - antagonists & inhibitors Galectin 1 - genetics Galectin 1 - metabolism galectin-1 Gene Expression Gene Knockdown Techniques Graft-versus-host reaction Hematologic and hematopoietic diseases Humans Immunomodulation Interleukin 10 Interleukin 2 Killer Cells, Natural - immunology Lectins Lymphocytes T Medical sciences Mesenchymal Stem Cells - immunology Mesenchymal Stem Cells - metabolism Mesenchyme Multipotent Stem Cells - immunology Multipotent Stem Cells - metabolism Natural killer cells stromal cells Stromal Cells - immunology Stromal Cells - metabolism Transfection Tumor necrosis factor- alpha
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