Gladiolic Acid: an Antifungal and Antibacterial Metabolic Product of Penicillium gladioli McCull and Thom

IT has been shown by Wilkins and Harris1, 2 that Penicillium gladioli produces an antibacterial substance when grown on liquid nutrient media. We have found that culture filtrates produced by this mould are toxic to fungi, the antifungal effect being more marked than the antibacterial effect. We have now succeeded in isolating the active substance in pure form from culture filtrates, yields as high as 300 mgm. per litre having been obtained, and have studied its biological and chemical properties.