Effect of calcitonin gene-related peptide on contraction of striated muscle in the mouse

We have found ultrastructurally calcitonin gene-related peptide-like immunoreactivity in the axon terminal within the synaptic trough of neuromuscular junction of the mouse. We determined, using pharmacological means, with a phrenic nerve-diaphragm preparation, that this peptide enhances muscle cont...

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Veröffentlicht in:	Neuroscience letters 1985-09, Vol.60 (2), p.227-230
Hauptverfasser:	Takami, Kenji, Kawai, Yuriko, Uchida, Shuji, Tohyama, Masaya, Shiotani, Yahe, Yoshida, Hiroshi, Emson, Piers C., Girgis, Samia, Hillyard, Carmel J., MacIntyre, Ian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Calcitonin Gene-Related Peptide contraction fine structure Fundamental and applied biological sciences. Psychology Male Mice mouse Muscle Contraction - drug effects Nerve Tissue Proteins - metabolism Nerve Tissue Proteins - pharmacology neuromuscular junction Neuromuscular Junction - metabolism neuromuscular junctions striated muscle Striated muscle. Tendons Vertebrates: osteoarticular system, musculoskeletal system
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Zusammenfassung:	We have found ultrastructurally calcitonin gene-related peptide-like immunoreactivity in the axon terminal within the synaptic trough of neuromuscular junction of the mouse. We determined, using pharmacological means, with a phrenic nerve-diaphragm preparation, that this peptide enhances muscle contraction during stimulation of the nerve fibers or direct stimulation of the muscle. This effect is probably brought about via the receptor for this peptide not the acetylcholine receptor.
ISSN:	0304-3940 1872-7972
DOI:	10.1016/0304-3940(85)90248-4