Bovine conglutinin (BC) mRNA expressed in liver: cloning and characterization of the BC cDNA reveals strong homology to surfactant protein-D

Bovine conglutinin (BC) is a C-type lectin isolated from bovine serum that appears to play a role in first-line host defense. The BC cDNA was cloned from a bovine liver library and the nucleotide (nt) sequence of 1519 bp was determined. The longest open reading frame encoded a 20-amino-acid (aa) sig...

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Veröffentlicht in:	Gene 1994-04, Vol.141 (2), p.277-281
Hauptverfasser:	Liou, Louis S, Sastry, Rajeswari, Hartshorn, Kevan L, Lee, Young Moo, Okarma, Thomas B, Tauber, Alfred I, Sastry, Kedarnath N
Format:	Artikel
Sprache:	eng
Schlagworte:	ADN RECOMBINADO ADN RECOMBINE Amino Acid Sequence Animals ARN MENSAJERO ARN MESSAGER Base Sequence Biological and medical sciences C-type lectin Cattle CLONACION CLONAGE CLONING Collectins FOIE Fundamental and applied biological sciences. Psychology Genes. Genome Glycoproteins - genetics HIGADO HIV-1 infection defense influenza virus inhibitor LECTINA LECTINE LECTINS LIVER Liver - metabolism MESSENGER RNA Molecular and cellular biology Molecular genetics Molecular Sequence Data NUCLEOTIDE SEQUENCE opsonin Organ Specificity Pulmonary Surfactant-Associated Protein D Pulmonary Surfactants - genetics RECOMBINANT DNA RNA, Messenger - biosynthesis SECUENCIA NUCLEICA Sequence Homology, Nucleic Acid SEQUENCE NUCLEIQUE Serum Globulins - genetics
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Zusammenfassung:	Bovine conglutinin (BC) is a C-type lectin isolated from bovine serum that appears to play a role in first-line host defense. The BC cDNA was cloned from a bovine liver library and the nucleotide (nt) sequence of 1519 bp was determined. The longest open reading frame encoded a 20-amino-acid (aa) signal sequence and a mature protein of 351 aa. Analysis of the nt and deduced aa sequences revealed 87 and 78% identity, respectively, with the sequences of another vertebrate lectin: bovine surfactant protein-D (SP-D). Of interest, the expression of the BC mRNA, as determined by RNase protection assay, is restricted to liver, unlike bovine SP-D, a lung-surfactant protein.
ISSN:	0378-1119 1879-0038
DOI:	10.1016/0378-1119(94)90585-1