RII and RIII type resistance of Plasmodium falciparum to combination of mefloquine and sulfadoxine/pyrimethamine in Indonesia

2 of 36 Plasmodium falciparum infections were resistant (RII and RIII) in vivo to the combination of mefloquine (M) and sulfadoxine-pyrimethamine (SP) in Jayapura, Irian Jaya, Indonesia. Expected absorption of mefloquine and pyrimethamine was confirmed in the one resistant patient from whom sera wer...

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Veröffentlicht in:	The Lancet (British edition) 1985-11, Vol.2 (8463), p.1039-1040
Hauptverfasser:	Hoffman, S L, Rustama, D, Dimpudus, A J, Punjabi, N H, Campbell, J R, Oetomo, H S, Marwoto, H A, Harun, S, Sukri, N, Heizmann, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Antimalarials - administration & dosage Antimalarials - pharmacology Antimalarials - therapeutic use Child Clinical Trials as Topic Drug Combinations - administration & dosage Drug Combinations - pharmacology Drug Resistance, Microbial Drug Therapy, Combination Female Humans Indonesia Malaria - drug therapy Malaria - parasitology Male Mefloquine Plasmodium falciparum - drug effects Pyrimethamine - administration & dosage Pyrimethamine - pharmacology Quinolines - pharmacology Quinolines - therapeutic use Random Allocation Sulfadoxine - administration & dosage Sulfadoxine - pharmacology Sulfanilamides - therapeutic use
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Zusammenfassung:	2 of 36 Plasmodium falciparum infections were resistant (RII and RIII) in vivo to the combination of mefloquine (M) and sulfadoxine-pyrimethamine (SP) in Jayapura, Irian Jaya, Indonesia. Expected absorption of mefloquine and pyrimethamine was confirmed in the one resistant patient from whom sera were available, and the isolate from this patient was sensitive to mefloquine in vitro. Only 2 of 41 infections studied at the same time were resistant in vivo to SP. There was no clinical advantage of MSP compared with SP, and limited observations suggest there may be a disadvantage.
ISSN:	0140-6736