Native α 2-macroglobulin binds to a surface component of human placental trophoblast

Native α 2-macroglobulin binds to a surface component of human placental trophoblast

Immunofluorescence and radiobinding studies have shown that native human α 2-macroglobulin (α 2M), but not α 2M-trypsin complexes, binds to isolated human placental syncytiotrophoblast microvillous plasma membrane vesicles. Inhibition studies have indicated tha α 2 M may bind to a trophoblast surfac...

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Veröffentlicht in:Placenta (Eastbourne) 1985-07, Vol.6 (4), p.323-328
Hauptverfasser: Johnson, P.M., Arnaud, P., Werner, P., Galbraith, R.M.
Format: Artikel
Sprache:eng
Schlagworte:
alpha-Macroglobulins - metabolism
Cell Membrane - metabolism
Female
Fluorescent Antibody Technique
Humans
Iodine Radioisotopes
Pregnancy
Trophoblasts - metabolism
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Zusammenfassung:Immunofluorescence and radiobinding studies have shown that native human α 2-macroglobulin (α 2M), but not α 2M-trypsin complexes, binds to isolated human placental syncytiotrophoblast microvillous plasma membrane vesicles. Inhibition studies have indicated tha α 2 M may bind to a trophoblast surface protease. This interaction is of significance for the control of trophoblast invasiveness and haemostasis within the placental bed.
ISSN:0143-4004
1532-3102
DOI:10.1016/S0143-4004(85)80041-2