Structural Clues to Prion Replication
Prion diseases generate when a protein with a pathological mutation converts other proteins to its form. A model for prion replication is presented that attempts to explain the pathogenesis of infectious, inherited and sporadic prion diseases.
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1994-04, Vol.264 (5158), p.530-531 |
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| container_end_page | 531 |
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| container_issue | 5158 |
| container_start_page | 530 |
| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 264 |
| creator | Cohen, Fred E. Pan, Keh-Ming Huang, Ziwei Baldwin, Michael Fletterick, Robert J. Prusiner, Stanley B. |
| description | Prion diseases generate when a protein with a pathological mutation converts other proteins to its form. A model for prion replication is presented that attempts to explain the pathogenesis of infectious, inherited and sporadic prion diseases. |
| doi_str_mv | 10.1126/science.7909169 |
| format | Article |
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A model for prion replication is presented that attempts to explain the pathogenesis of infectious, inherited and sporadic prion diseases.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.7909169</identifier><identifier>PMID: 7909169</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Society for the Advancement of Science</publisher><subject>Algorithms ; Amino acids ; Anatomy ; Animals ; Biochemistry ; Biological and medical sciences ; Bone diseases ; Creutzfeldt Jakob syndrome ; Development and progression ; Disease ; Disease models ; Fundamental and applied biological sciences. Psychology ; Genetic mutation ; Genetics ; Infections ; Medical research ; Mice ; Mice, Transgenic ; Microbiology ; Models, Biological ; Mutation ; Nervous system diseases ; Observation ; Peripheral nervous system diseases ; Perspectives ; Prion diseases ; Prion Diseases - metabolism ; Prion Diseases - transmission ; Prions ; Prions (Proteins) ; Prions - biosynthesis ; Prions - chemistry ; Prions - genetics ; Prions - metabolism ; Protein Conformation ; Protein Structure, Secondary ; PrPSc Proteins ; Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains ; Virology</subject><ispartof>Science (American Association for the Advancement of Science), 1994-04, Vol.264 (5158), p.530-531</ispartof><rights>Copyright 1994 American Association for the Advancement of Science</rights><rights>1994 INIST-CNRS</rights><rights>COPYRIGHT 1994 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1994 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Apr 22, 1994</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c644t-68041736618a1e5a6e9300c29e337086c3abf4d5d1ede01ee3ca2460b153f78c3</citedby><cites>FETCH-LOGICAL-c644t-68041736618a1e5a6e9300c29e337086c3abf4d5d1ede01ee3ca2460b153f78c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2883697$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2883697$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,778,782,801,2873,2874,27911,27912,58004,58237</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4080967$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7909169$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cohen, Fred E.</creatorcontrib><creatorcontrib>Pan, Keh-Ming</creatorcontrib><creatorcontrib>Huang, Ziwei</creatorcontrib><creatorcontrib>Baldwin, Michael</creatorcontrib><creatorcontrib>Fletterick, Robert J.</creatorcontrib><creatorcontrib>Prusiner, Stanley B.</creatorcontrib><title>Structural Clues to Prion Replication</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Prion diseases generate when a protein with a pathological mutation converts other proteins to its form. 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| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1994-04, Vol.264 (5158), p.530-531 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76447478 |
| source | MEDLINE; American Association for the Advancement of Science; Jstor Complete Legacy |
| subjects | Algorithms Amino acids Anatomy Animals Biochemistry Biological and medical sciences Bone diseases Creutzfeldt Jakob syndrome Development and progression Disease Disease models Fundamental and applied biological sciences. Psychology Genetic mutation Genetics Infections Medical research Mice Mice, Transgenic Microbiology Models, Biological Mutation Nervous system diseases Observation Peripheral nervous system diseases Perspectives Prion diseases Prion Diseases - metabolism Prion Diseases - transmission Prions Prions (Proteins) Prions - biosynthesis Prions - chemistry Prions - genetics Prions - metabolism Protein Conformation Protein Structure, Secondary PrPSc Proteins Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains Virology |
| title | Structural Clues to Prion Replication |
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