Structural Clues to Prion Replication

Prion diseases generate when a protein with a pathological mutation converts other proteins to its form. A model for prion replication is presented that attempts to explain the pathogenesis of infectious, inherited and sporadic prion diseases.

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Bibliographische Detailangaben
Veröffentlicht in:	Science (American Association for the Advancement of Science) 1994-04, Vol.264 (5158), p.530-531
Hauptverfasser:	Cohen, Fred E., Pan, Keh-Ming, Huang, Ziwei, Baldwin, Michael, Fletterick, Robert J., Prusiner, Stanley B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Amino acids Anatomy Animals Biochemistry Biological and medical sciences Bone diseases Creutzfeldt Jakob syndrome Development and progression Disease Disease models Fundamental and applied biological sciences. Psychology Genetic mutation Genetics Infections Medical research Mice Mice, Transgenic Microbiology Models, Biological Mutation Nervous system diseases Observation Peripheral nervous system diseases Perspectives Prion diseases Prion Diseases - metabolism Prion Diseases - transmission Prions Prions (Proteins) Prions - biosynthesis Prions - chemistry Prions - genetics Prions - metabolism Protein Conformation Protein Structure, Secondary PrPSc Proteins Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains Virology
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Beschreibung
Zusammenfassung:	Prion diseases generate when a protein with a pathological mutation converts other proteins to its form. A model for prion replication is presented that attempts to explain the pathogenesis of infectious, inherited and sporadic prion diseases.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.7909169