Resection of Chest Wall and Central Veins for Invasive Cutaneous Aspergillus Infection in an Immunocompromised Patient

Primary cutaneous invasive Aspergillus infection at a Hickman catheter site led to chest wall involvement and central venous suppurative thrombophlebitis in a patient with relapsed acute myelogenous leukemia. Therapy included high-dose amphotericin B, serial wound debridements pending bone marrow recovery, and definitive resection of the infected chest wall and thrombosed internal jugular, subclavian, and innominate veins. To our knowledge, this procedure for control of invasive fungal infection has not been reported previously.