Two New Cytotoxic Peroxide-Containing Acids from a New Guinea Sponge, Callyspongia sp

Two new C14 cytotoxic, branched-chain acids, 1 and 2, containing a cyclic peroxide moiety were isolated from a sponge, Callyspongia sp., collected in New Guinea. The structures were elucidated through extensive spectral analysis.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 1994-01, Vol.57 (1), p.123-127
Hauptverfasser:	Toth, Steven I, Schmitz, Francis J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates - isolation & purification Acetates - pharmacology Animals Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Biological and medical sciences Callyspongia CHEMICAL COMPOSITION Chromatography, Thin Layer COMPOSICION QUIMICA COMPOSITION CHIMIQUE Dioxanes - isolation & purification Dioxanes - pharmacology Drug Screening Assays, Antitumor EPONGE ESPECTROMETRIA ESPONJAS General pharmacology Leukemia P388 - drug therapy Magnetic Resonance Spectroscopy Marine Medical sciences Mice MOLECULAR CONFORMATION molecular structure New Guinea PAPOUASIE NOUVELLE GUINEE PAPUA NEW GUINEA PAPUA NUEVA GUINEA Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Porifera - chemistry SPECTRAL ANALYSIS SPECTROMETRIE SPECTROMETRY SPONGES
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Beschreibung
Zusammenfassung:	Two new C14 cytotoxic, branched-chain acids, 1 and 2, containing a cyclic peroxide moiety were isolated from a sponge, Callyspongia sp., collected in New Guinea. The structures were elucidated through extensive spectral analysis.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np50103a017