A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERG
The t(11;22)(q24;q12), present in 85% of Ewing's sarcoma and related tumours, fuses the EWS gene from chromosome 22q12 and the ETS family member, FLI–1 . This results in the expression of a chimaeric protein containing the amino–terminal portion of EWS fused to the ETS DMA–binding domain of FLI...
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Veröffentlicht in: | Nature genetics 1994-02, Vol.6 (2), p.146-151 |
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Sprache: | eng |
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Zusammenfassung: | The t(11;22)(q24;q12), present in 85% of Ewing's sarcoma and related tumours, fuses the EWS gene from chromosome 22q12 and the
ETS
family member,
FLI–1
. This results in the expression of a chimaeric protein containing the amino–terminal portion of EWS fused to the ETS DMA–binding domain of FLI–1. We have identified a second Ewing's sarcoma translocation, t(21;22)(q22;q12), that fuses
EWS
to a different
ETS
family member, the ERG gene located on band 21q22. Identical
EWS
nucleotide sequences found in the
EWS/FLI–1
fusion transcripts are fused to portions of
ERG
encoding an ETS DNA–binding domain resulting in expression of a hybrid
EWS/ERG
protein. These findings suggest that fusion of
EWS
to different members of the
ETS
family of transcription factor genes may result in the expression of similar disease phenotypes. |
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ISSN: | 1061-4036 1546-1718 |
DOI: | 10.1038/ng0294-146 |