Imipramine in Patients with Chest Pain Despite Normal Coronary Angiograms

Ten to 30 percent of patients with chest pain sufficiently similar to angina to justify cardiac catheterization are found to have normal coronary angiograms 1 – 6 . Despite a good prognosis and the beneficial effect of reassurance for many patients, most continue to have chest pain that may result in visits to the emergency room, admission to the coronary care unit, and even repeat cardiac catheterization 1 – 5 , 7 _ 9 . Thus, an apparently benign condition may have considerable adverse effects on the quality of life, employment, and the use of health care resources, with the attendant expenses. Several possible causes of . . .