Equilibrium of conformers in solution: spin-labelled angiotensin

Equilibrium of conformers in solution: spin-labelled angiotensin

The number of structural parameters were determined for spin-labelled angiotensin in aqueous solution with the use of fluorescence spectroscopy and 1H NMR relaxation induced by the spin label. At the same time all measured parameters were estimated theoretically by means of energy calculations and M...

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Veröffentlicht in:FEBS letters 1985-11, Vol.192 (1), p.128-130
Hauptverfasser: Vesterman, B., Sekacis, I., Bētiņš, J., Podiņš, L., Nikiforovich, G.V.
Format: Artikel
Sprache:eng
Schlagworte:
Angiotensin
Angiotensin II
Biological and medical sciences
Cyclic N-Oxides
Energy calculation
equilibrium
fluorescence
Free Radicals
Fundamental and applied biological sciences. Psychology
Magnetic Resonance Spectroscopy
Molecular biophysics
Molecular Conformation
N.M.R
NMR relaxation
Peptide solution conformation
Solutions
spectroscopy
Spin Labels
Structure in molecular biology
Thermodynamics
Tridimensional structure
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Zusammenfassung:The number of structural parameters were determined for spin-labelled angiotensin in aqueous solution with the use of fluorescence spectroscopy and 1H NMR relaxation induced by the spin label. At the same time all measured parameters were estimated theoretically by means of energy calculations and Monte-Carlo techniques. The matching procedure for experimental and computational data allows one to suggest a dynamic equilibrium between conformers of the molecule in aqueous solution and to estimate the values of their weights.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(85)80057-0