3-Alkanoyl-5-hydroxymethyl tetronic acid homologues and resistomycin : new inhibitors of HIV-1 protease. I: Fermentation, isolation and biological activity

In the course of a screening program for HIV-1 protease inhibiting activity, six new homologues of 3-alkanoyl-5-hydroxymethyl tetronic acids (1 approximately 6) and the known natural product resistomycin (7) were isolated from cultures of the Actinomycete strain DSM 7357. The substituted tetronic ac...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of antibiotics 1994, Vol.47 (2), p.136-142
Hauptverfasser:	ROGGO, B. E, PETERSEN, F, DELMENDO, R, JENNY, H.-B, PETER, H. H, ROESEL, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Actinomycetaceae - chemistry AIDS/HIV Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Benzopyrenes - chemistry Benzopyrenes - isolation & purification Benzopyrenes - pharmacology Biological and medical sciences Fermentation Furans - chemistry Furans - isolation & purification Furans - pharmacology General pharmacology HIV Protease Inhibitors - chemistry HIV Protease Inhibitors - isolation & purification HIV Protease Inhibitors - pharmacology human immunodeficiency virus 1 Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	In the course of a screening program for HIV-1 protease inhibiting activity, six new homologues of 3-alkanoyl-5-hydroxymethyl tetronic acids (1 approximately 6) and the known natural product resistomycin (7) were isolated from cultures of the Actinomycete strain DSM 7357. The substituted tetronic acids belong to a recently described structural class of secondary metabolites. The HIV-1 activity of resistomycin (7) has not been reported before.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.47.136