Influences of Alkylphenyl α-D-Mannopyranosides on Histamine Release from Rat Peritoneal Mast Cells Induced by Concanavalin A

The influence of mannose, glucose, galactose and their corresponding methyl and phenyl glycopyranosides, as well as a series of alkylphenyl α-D-mannopyranosides, on histamine release from rat peritoneal mast cells induced by concanavalin A was examined. Among the compounds tested, the inhibitory effects of compounds bearing a 2, 6-dimethyl substituent were stronger than the others. The results suggest that the binding ability of phenyl α-D-mannopyranoside may be markedly enchanced by the introduction of a 2, 6-dimethyl substituent into the benzene nuclei of aglycones.