A cloned sequence, p82H, of the alphoid repeated DNA family found at the centromeres of all human chromosomes

Clone p82H is a human DNA sequence which hybridises in situ exclusively to the centromeric regions of all human chromosomes. It is composed of approximately 14 tandemly repeated variants of a basic 172 bp sequence, and is related to the alphoid family. The organisation of the family of cross-hybridi...

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Veröffentlicht in:	Chromosoma 1985-01, Vol.92 (5), p.369-377
Hauptverfasser:	Mitchell, A R, Gosden, J R, Miller, D A
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Centromere - ultrastructure Chromosomes - ultrastructure Chromosomes, Human - ultrastructure Cloning, Molecular DNA - genetics DNA Restriction Enzymes DNA Transposable Elements Escherichia coli - genetics Humans Hybrid Cells - cytology Male Nucleic Acid Hybridization Repetitive Sequences, Nucleic Acid Spermatozoa
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Beschreibung
Zusammenfassung:	Clone p82H is a human DNA sequence which hybridises in situ exclusively to the centromeric regions of all human chromosomes. It is composed of approximately 14 tandemly repeated variants of a basic 172 bp sequence, and is related to the alphoid family. The organisation of the family of cross-hybridising sequences, detected by the clone p82H, is described both in the human genome and on certain chromosomes, and its relationship to known sequence families is discussed.
ISSN:	0009-5915 1432-0886
DOI:	10.1007/bf00327469