Greater Sensitivity of Human Multidrug-Resistant (mdr) Cancer Cells to Polyunsaturated Fatty Acids Than Their Non-mdr Counterparts

A study found that multidrug-resistant cells are more sensitive than nontumorigenic cells to ethyl gamma-linolenate (GLA) and methyl eicosapentaenoiate (EPA). Results suggest that EPA and GLA treatment offers an alternative for patients with resistance to anticancer drugs.

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Bibliographische Detailangaben
Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 1994-04, Vol.86 (8), p.638-639
Hauptverfasser:	WEBER, JOSEPH M., SIRCAR, SUCHETA, BEGIN, MICHEL E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Cancer Drug Resistance Fatty Acids, Unsaturated - pharmacology Humans Medical research Oils & fats Therapy Tumor Cells, Cultured - drug effects
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	A study found that multidrug-resistant cells are more sensitive than nontumorigenic cells to ethyl gamma-linolenate (GLA) and methyl eicosapentaenoiate (EPA). Results suggest that EPA and GLA treatment offers an alternative for patients with resistance to anticancer drugs.
ISSN:	0027-8874 1460-2105
DOI:	10.1093/jnci/86.8.638