Genetic associations with human longevity at the APOE and ACE loci
In an effort to dissect the genetic components of longevity, we have undertaken case–control studies of populations of centenarians ( n =338) and adults aged 20–70 years at several polymorphic candidate gene loci. Here we report results on two genes, chosen for their impact on cardiovascular risk, e...
Gespeichert in:
| Veröffentlicht in: | Nature genetics 1994-01, Vol.6 (1), p.29-32 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 32 |
|---|---|
| container_issue | 1 |
| container_start_page | 29 |
| container_title | Nature genetics |
| container_volume | 6 |
| creator | Schächter, François Faure-Delanef, Laurence Guénot, Frédérique Rouger, Hervé Froguel, Philippe Lesueur-Ginot, Laurence Cohen, Daniel |
| description | In an effort to dissect the genetic components of longevity, we have undertaken case–control studies of populations of centenarians (
n
=338) and adults aged 20–70 years at several polymorphic candidate gene loci. Here we report results on two genes, chosen for their impact on cardiovascular risk, encoding apolipoprotein E (ApoE), angiotensin–converting enzyme (ACE). We find that the ε4 allele of
APOE
, which promotes premature atherosclerosis, is significantly less frequent in centenarians than in controls (p |
| doi_str_mv | 10.1038/ng0194-29 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_76409884</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>16690258</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-1303f44816102d9c470a3fe38610290e0835c72831198282571d9c0b719999313</originalsourceid><addsrcrecordid>eNqFkE1LxDAQhoMo6_px8AcIOYigUJ1J0jY5rsv6AcJ60HOJ2XQ3S5uuTav4782yxZPgXGaG92EGHkLOEG4QuLz1S0AlEqb2yBhTkSWYo9yPM2SYCODZITkKYQ2AQoAckZFEnkmmxuTuwXrbOUN1CI1xunOND_TLdSu66mvtadX4pf103TfVHe1Wlk5e5jOq_YJOprOYGndCDkpdBXs69GPydj97nT4mz_OHp-nkOTE8T7sEOfBSCIkZAlsoI3LQvLRcbncFFiRPTc4kR1SSSZbmGCl4z1HF4siPyeXu7qZtPnobuqJ2wdiq0t42fSjyTICSUvwLYpYpYKmM4NUONG0TQmvLYtO6WrffBUKxFVvsxBZMRfZ8ONq_13bxSw4mY34x5DoYXZWt9saFX0ygAsHyiF3vsBCTaLYt1k3f-ujtj58_9taJPg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16690258</pqid></control><display><type>article</type><title>Genetic associations with human longevity at the APOE and ACE loci</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><source>Nature</source><creator>Schächter, François ; Faure-Delanef, Laurence ; Guénot, Frédérique ; Rouger, Hervé ; Froguel, Philippe ; Lesueur-Ginot, Laurence ; Cohen, Daniel</creator><creatorcontrib>Schächter, François ; Faure-Delanef, Laurence ; Guénot, Frédérique ; Rouger, Hervé ; Froguel, Philippe ; Lesueur-Ginot, Laurence ; Cohen, Daniel</creatorcontrib><description>In an effort to dissect the genetic components of longevity, we have undertaken case–control studies of populations of centenarians (
n
=338) and adults aged 20–70 years at several polymorphic candidate gene loci. Here we report results on two genes, chosen for their impact on cardiovascular risk, encoding apolipoprotein E (ApoE), angiotensin–converting enzyme (ACE). We find that the ε4 allele of
APOE
, which promotes premature atherosclerosis, is significantly less frequent in centenarians than in controls (p<0.001), while the frequency of the ε2 allele, associated previously with type III and IV hyperlipidemia, is significantly increased (p<0.01). A variant of ACE which predisposes to coronary heart disease is surprisingly more frequent in centenarians, with a significant increase of the homozygous genotype (p<0.01). These associations provide examples of genetic influences on differential survival and may point to pleiotropic age–dependent effects on longevity.</description><identifier>ISSN: 1061-4036</identifier><identifier>EISSN: 1546-1718</identifier><identifier>DOI: 10.1038/ng0194-29</identifier><identifier>PMID: 8136829</identifier><identifier>CODEN: NGENEC</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Agriculture ; Alleles ; Animal Genetics and Genomics ; Apolipoproteins E - genetics ; Base Sequence ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Case-Control Studies ; Classical genetics, quantitative genetics, hybrids ; Female ; France - epidemiology ; Fundamental and applied biological sciences. Psychology ; Gene Frequency ; Gene Function ; Genetics of eukaryotes. Biological and molecular evolution ; Genotype ; Human ; Human Genetics ; Humans ; Longevity - genetics ; Male ; Middle Aged ; Molecular Sequence Data ; Peptidyl-Dipeptidase A - genetics ; Polymorphism, Genetic ; Sex Characteristics</subject><ispartof>Nature genetics, 1994-01, Vol.6 (1), p.29-32</ispartof><rights>Springer Nature America, Inc. 1994</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-1303f44816102d9c470a3fe38610290e0835c72831198282571d9c0b719999313</citedby><cites>FETCH-LOGICAL-c375t-1303f44816102d9c470a3fe38610290e0835c72831198282571d9c0b719999313</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/ng0194-29$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/ng0194-29$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,4010,27900,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4190427$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8136829$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schächter, François</creatorcontrib><creatorcontrib>Faure-Delanef, Laurence</creatorcontrib><creatorcontrib>Guénot, Frédérique</creatorcontrib><creatorcontrib>Rouger, Hervé</creatorcontrib><creatorcontrib>Froguel, Philippe</creatorcontrib><creatorcontrib>Lesueur-Ginot, Laurence</creatorcontrib><creatorcontrib>Cohen, Daniel</creatorcontrib><title>Genetic associations with human longevity at the APOE and ACE loci</title><title>Nature genetics</title><addtitle>Nat Genet</addtitle><addtitle>Nat Genet</addtitle><description>In an effort to dissect the genetic components of longevity, we have undertaken case–control studies of populations of centenarians (
n
=338) and adults aged 20–70 years at several polymorphic candidate gene loci. Here we report results on two genes, chosen for their impact on cardiovascular risk, encoding apolipoprotein E (ApoE), angiotensin–converting enzyme (ACE). We find that the ε4 allele of
APOE
, which promotes premature atherosclerosis, is significantly less frequent in centenarians than in controls (p<0.001), while the frequency of the ε2 allele, associated previously with type III and IV hyperlipidemia, is significantly increased (p<0.01). A variant of ACE which predisposes to coronary heart disease is surprisingly more frequent in centenarians, with a significant increase of the homozygous genotype (p<0.01). These associations provide examples of genetic influences on differential survival and may point to pleiotropic age–dependent effects on longevity.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Agriculture</subject><subject>Alleles</subject><subject>Animal Genetics and Genomics</subject><subject>Apolipoproteins E - genetics</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Case-Control Studies</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>Female</subject><subject>France - epidemiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Frequency</subject><subject>Gene Function</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Genotype</subject><subject>Human</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Longevity - genetics</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Molecular Sequence Data</subject><subject>Peptidyl-Dipeptidase A - genetics</subject><subject>Polymorphism, Genetic</subject><subject>Sex Characteristics</subject><issn>1061-4036</issn><issn>1546-1718</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMo6_px8AcIOYigUJ1J0jY5rsv6AcJ60HOJ2XQ3S5uuTav4782yxZPgXGaG92EGHkLOEG4QuLz1S0AlEqb2yBhTkSWYo9yPM2SYCODZITkKYQ2AQoAckZFEnkmmxuTuwXrbOUN1CI1xunOND_TLdSu66mvtadX4pf103TfVHe1Wlk5e5jOq_YJOprOYGndCDkpdBXs69GPydj97nT4mz_OHp-nkOTE8T7sEOfBSCIkZAlsoI3LQvLRcbncFFiRPTc4kR1SSSZbmGCl4z1HF4siPyeXu7qZtPnobuqJ2wdiq0t42fSjyTICSUvwLYpYpYKmM4NUONG0TQmvLYtO6WrffBUKxFVvsxBZMRfZ8ONq_13bxSw4mY34x5DoYXZWt9saFX0ygAsHyiF3vsBCTaLYt1k3f-ujtj58_9taJPg</recordid><startdate>19940101</startdate><enddate>19940101</enddate><creator>Schächter, François</creator><creator>Faure-Delanef, Laurence</creator><creator>Guénot, Frédérique</creator><creator>Rouger, Hervé</creator><creator>Froguel, Philippe</creator><creator>Lesueur-Ginot, Laurence</creator><creator>Cohen, Daniel</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19940101</creationdate><title>Genetic associations with human longevity at the APOE and ACE loci</title><author>Schächter, François ; Faure-Delanef, Laurence ; Guénot, Frédérique ; Rouger, Hervé ; Froguel, Philippe ; Lesueur-Ginot, Laurence ; Cohen, Daniel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-1303f44816102d9c470a3fe38610290e0835c72831198282571d9c0b719999313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Agriculture</topic><topic>Alleles</topic><topic>Animal Genetics and Genomics</topic><topic>Apolipoproteins E - genetics</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Case-Control Studies</topic><topic>Classical genetics, quantitative genetics, hybrids</topic><topic>Female</topic><topic>France - epidemiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Frequency</topic><topic>Gene Function</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Genotype</topic><topic>Human</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Longevity - genetics</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Molecular Sequence Data</topic><topic>Peptidyl-Dipeptidase A - genetics</topic><topic>Polymorphism, Genetic</topic><topic>Sex Characteristics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schächter, François</creatorcontrib><creatorcontrib>Faure-Delanef, Laurence</creatorcontrib><creatorcontrib>Guénot, Frédérique</creatorcontrib><creatorcontrib>Rouger, Hervé</creatorcontrib><creatorcontrib>Froguel, Philippe</creatorcontrib><creatorcontrib>Lesueur-Ginot, Laurence</creatorcontrib><creatorcontrib>Cohen, Daniel</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Nature genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schächter, François</au><au>Faure-Delanef, Laurence</au><au>Guénot, Frédérique</au><au>Rouger, Hervé</au><au>Froguel, Philippe</au><au>Lesueur-Ginot, Laurence</au><au>Cohen, Daniel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic associations with human longevity at the APOE and ACE loci</atitle><jtitle>Nature genetics</jtitle><stitle>Nat Genet</stitle><addtitle>Nat Genet</addtitle><date>1994-01-01</date><risdate>1994</risdate><volume>6</volume><issue>1</issue><spage>29</spage><epage>32</epage><pages>29-32</pages><issn>1061-4036</issn><eissn>1546-1718</eissn><coden>NGENEC</coden><abstract>In an effort to dissect the genetic components of longevity, we have undertaken case–control studies of populations of centenarians (
n
=338) and adults aged 20–70 years at several polymorphic candidate gene loci. Here we report results on two genes, chosen for their impact on cardiovascular risk, encoding apolipoprotein E (ApoE), angiotensin–converting enzyme (ACE). We find that the ε4 allele of
APOE
, which promotes premature atherosclerosis, is significantly less frequent in centenarians than in controls (p<0.001), while the frequency of the ε2 allele, associated previously with type III and IV hyperlipidemia, is significantly increased (p<0.01). A variant of ACE which predisposes to coronary heart disease is surprisingly more frequent in centenarians, with a significant increase of the homozygous genotype (p<0.01). These associations provide examples of genetic influences on differential survival and may point to pleiotropic age–dependent effects on longevity.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>8136829</pmid><doi>10.1038/ng0194-29</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1061-4036 |
| ispartof | Nature genetics, 1994-01, Vol.6 (1), p.29-32 |
| issn | 1061-4036 1546-1718 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76409884 |
| source | MEDLINE; Springer Nature - Complete Springer Journals; Nature |
| subjects | Adult Aged Aged, 80 and over Agriculture Alleles Animal Genetics and Genomics Apolipoproteins E - genetics Base Sequence Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Case-Control Studies Classical genetics, quantitative genetics, hybrids Female France - epidemiology Fundamental and applied biological sciences. Psychology Gene Frequency Gene Function Genetics of eukaryotes. Biological and molecular evolution Genotype Human Human Genetics Humans Longevity - genetics Male Middle Aged Molecular Sequence Data Peptidyl-Dipeptidase A - genetics Polymorphism, Genetic Sex Characteristics |
| title | Genetic associations with human longevity at the APOE and ACE loci |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T14%3A24%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Genetic%20associations%20with%20human%20longevity%20at%20the%20APOE%20and%20ACE%20loci&rft.jtitle=Nature%20genetics&rft.au=Sch%C3%A4chter,%20Fran%C3%A7ois&rft.date=1994-01-01&rft.volume=6&rft.issue=1&rft.spage=29&rft.epage=32&rft.pages=29-32&rft.issn=1061-4036&rft.eissn=1546-1718&rft.coden=NGENEC&rft_id=info:doi/10.1038/ng0194-29&rft_dat=%3Cproquest_cross%3E16690258%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16690258&rft_id=info:pmid/8136829&rfr_iscdi=true |