Genetic associations with human longevity at the APOE and ACE loci

In an effort to dissect the genetic components of longevity, we have undertaken case–control studies of populations of centenarians ( n =338) and adults aged 20–70 years at several polymorphic candidate gene loci. Here we report results on two genes, chosen for their impact on cardiovascular risk, e...

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Veröffentlicht in:	Nature genetics 1994-01, Vol.6 (1), p.29-32
Hauptverfasser:	Schächter, François, Faure-Delanef, Laurence, Guénot, Frédérique, Rouger, Hervé, Froguel, Philippe, Lesueur-Ginot, Laurence, Cohen, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Agriculture Alleles Animal Genetics and Genomics Apolipoproteins E - genetics Base Sequence Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Case-Control Studies Classical genetics, quantitative genetics, hybrids Female France - epidemiology Fundamental and applied biological sciences. Psychology Gene Frequency Gene Function Genetics of eukaryotes. Biological and molecular evolution Genotype Human Human Genetics Humans Longevity - genetics Male Middle Aged Molecular Sequence Data Peptidyl-Dipeptidase A - genetics Polymorphism, Genetic Sex Characteristics
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Zusammenfassung:	In an effort to dissect the genetic components of longevity, we have undertaken case–control studies of populations of centenarians ( n =338) and adults aged 20–70 years at several polymorphic candidate gene loci. Here we report results on two genes, chosen for their impact on cardiovascular risk, encoding apolipoprotein E (ApoE), angiotensin–converting enzyme (ACE). We find that the ε4 allele of APOE , which promotes premature atherosclerosis, is significantly less frequent in centenarians than in controls (p
ISSN:	1061-4036 1546-1718
DOI:	10.1038/ng0194-29