Immunogenicity and evolutionary variability of epitopes within IgA1 protease from serogroup A Neisseria meningitidis

Summary Five murine epitopes were defined and mapped within IgA1 protease produced by Neisseria meningitidis. Epitopes 1 and 2 were present in IgA1 protease from all strains, and from Neisseria gonorrhoeae. Epitopes 3 through to 5 varied between subgroups of serogroup A meningococci. but have remain...

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Veröffentlicht in:Molecular microbiology 1994-01, Vol.11 (1), p.175-187
Hauptverfasser: Morelli, Giovanna, Valle, Jesus, Lammel, Claudia J., Pohlner, Johannes, Müller, Kerstin, Blake, Milan, Brooks, Geo. F., Meyer, Thomas F., Koumaré, Brehima, Brieske, Norbert, Achtman, Mark
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Sprache:eng
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Zusammenfassung:Summary Five murine epitopes were defined and mapped within IgA1 protease produced by Neisseria meningitidis. Epitopes 1 and 2 were present in IgA1 protease from all strains, and from Neisseria gonorrhoeae. Epitopes 3 through to 5 varied between subgroups of serogroup A meningococci. but have remained constant over decades within the subgroups, except for epitope 4, which changed between 1983 and 1987 during the spread of subgroup III meningococci from Asia to Africa. Binding of monoclonal antibodies to epitopes 1, 4 and 5 neutralized enzymatic function. Human sera containing antibodies to lgA1 protease as a result of natural infection inhibited binding of monoclonal antibodies to epitope 4 but not to the other epitopes.
ISSN:0950-382X
1365-2958
DOI:10.1111/j.1365-2958.1994.tb00299.x