Detrusor inhibition in suprasacral spinal cord injuries: is it due to sympathetic overactivity?

The authors report five patients with detrusor inactivity in suprasacral spinal cord lesions with perineal spasticity. In all of these cases with cervical or high thoracic lesions treatment with an alpha-blocking drug (Phenoxybenzamine) allowed bladder activity to return. These results suggest that...

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Veröffentlicht in:	Paraplegia 1985-08, Vol.23 (4), p.201-206
Hauptverfasser:	MATHE, J. F, LABAT, J. J, LANOISELEE, J. M, BUZELIN, J. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Biological and medical sciences Humans Injections, Intravenous Injuries of the nervous system and the skull. Diseases due to physical agents Lumbosacral Region Male Medical sciences Muscle Contraction Muscle, Smooth - physiopathology Phenoxybenzamine - therapeutic use Pressure Spinal Cord Injuries - physiopathology Sympathetic Nervous System - physiopathology Time Factors Traumas. Diseases due to physical agents Urethra - physiopathology Urinary Bladder - physiopathology Urination - drug effects
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Zusammenfassung:	The authors report five patients with detrusor inactivity in suprasacral spinal cord lesions with perineal spasticity. In all of these cases with cervical or high thoracic lesions treatment with an alpha-blocking drug (Phenoxybenzamine) allowed bladder activity to return. These results suggest that the sacral parasympathetic centre is under the inhibitory influence of the sympathetic nervous system.
ISSN:	0031-1758 1362-4393 1476-5624
DOI:	10.1038/sc.1985.36