Effects of Peripheral Cold Exposure on Microvascular Dynamics in Systemic Sclerosis

Objective. To determine the influence of cold exposure on microvascular permeability in systemic sclerosis (SSc). Methods. Thirteen patients with SSc were studied by dynamic fluorescence videomicroscopy under basal conditions and after exposure to cold. Results. Exposure to cold caused a significant...

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Veröffentlicht in:	Arthritis and rheumatism 1994-03, Vol.37 (3), p.384-390
Hauptverfasser:	Grassi, Walter, Core, Paolo, Carlino, Giorgio, Cervini, Claudio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological and medical sciences Capillary Permeability Cold Temperature Female Fingers - blood supply Hemodynamics Humans Image Processing, Computer-Assisted Medical sciences Microcirculation - physiopathology Microscopy, Fluorescence Middle Aged Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Scleroderma, Systemic - physiopathology
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Zusammenfassung:	Objective. To determine the influence of cold exposure on microvascular permeability in systemic sclerosis (SSc). Methods. Thirteen patients with SSc were studied by dynamic fluorescence videomicroscopy under basal conditions and after exposure to cold. Results. Exposure to cold caused a significant reduction in the interstitial concentration of sodium fluorescein (P < 0.05 to 0.001). Conclusion. Our findings show that cold exposure has a striking effect on microvascular dynamics in SSc.
ISSN:	0004-3591 1529-0131
DOI:	10.1002/art.1780370312