Effects of Endurance Training on the Androgenic Response to Exercise in Man

Abstract Six healthy subjects, aged 35.8 ± 4.4 years, volunteered to participate in a 40-week training program on a bicycle ergometer [three 60-min sessions per week at 80%-85% of maximal oxygen uptake (V̇O 2 max). Before training and at the 10 th , 20 th , 30 th , and 40 tn weeks of the training program, plasma testosterone, Cortisol, and androstenedione concentrations were measured at rest (t 0 ) and at the end (t 60 ) of a 1-h endurance exercise requiring 85%-90% of V̇O 2 max. Training resulted in significant increases of anaerobic threshold (12.6%) and V̇O 2 max (7.3%). The training program did not significantly alter the resting values of plasma testosterone, androstenedione, and Cortisol; in contrast, the exercise responses (Δ = t 60 -t 0 ) of testosterone, androstenedione, and Cortisol were increased. The highest amplitude of these responses was reached at the 30 th week for Cortisol and androstenedione and at the 40 th for testosterone. These results suggest that long-term training enhances both testicular adrenal and responses to endurance exercise. The possible role of hormonal changes in the mobilization of energy substrates during exercise is discussed.