Effect of spectrin dimer on actin polymerization

Effect of spectrin dimer on actin polymerization

Spectrin dimer is shown to influence the polymerization behaviour of actin. The polymerization of both Mg 2+- and Ca 2+-actin is regulated by an enhancement in the rate of nucleation and a fragmentation of preformed actin filaments. In addition, spectrin decreases the critical concentration of Ca 2+...

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Veröffentlicht in:FEBS letters 1985-10, Vol.190 (1), p.15-20
Hauptverfasser: Strömqvist, Mats, Backman, Lars, Shanbhag, Vithaldas P.
Format: Artikel
Sprache:eng
Schlagworte:
Actin
Actin polymerization
Actins
Analytical, structural and metabolic biochemistry
Animals
Band 4.1
Binding Sites
Biological and medical sciences
Biopolymers
Blood Proteins
Calcium
Chemical Phenomena
Chemistry
Contractile proteins
Cytoskeletal Proteins
Cytoskeleton
Erythrocyte
Fundamental and applied biological sciences. Psychology
Holoproteins
Magnesium
Membrane Proteins
Neuropeptides
Proteins
Rabbits
Spectrin
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Zusammenfassung:Spectrin dimer is shown to influence the polymerization behaviour of actin. The polymerization of both Mg 2+- and Ca 2+-actin is regulated by an enhancement in the rate of nucleation and a fragmentation of preformed actin filaments. In addition, spectrin decreases the critical concentration of Ca 2+-actin but not that of Mg 2+-actin. This suggests that the two types of actin may differ in their interaction with spectrin dimer probably due to the different conformations. Band 4.1 elevates the effects of spectrin under non-equilibrium conditions but its contribution is less at steady state.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(85)80417-8