An iodinated ligand identifying the D-1 dopamine receptor
Iodination (with 125I) of SKF 83692 (2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol) produces a ligand of high specific activity. In the caudate nucleus of rat brain, this ligand binds to a site which discriminates between the active and inactive enantiomers of drugs selective for the D-1...
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| Veröffentlicht in: | European journal of pharmacology 1985-07, Vol.113 (3), p.437-440 |
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| container_end_page | 440 |
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| container_issue | 3 |
| container_start_page | 437 |
| container_title | European journal of pharmacology |
| container_volume | 113 |
| creator | Sidhu, Anita Kebabian, John W. |
| description | Iodination (with
125I) of SKF 83692 (2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol) produces a ligand of high specific activity. In the caudate nucleus of rat brain, this ligand binds to a site which discriminates between the active and inactive enantiomers of drugs selective for the D-1 receptor but which does not recognize drugs selective for the D-2 dopamine receptor or a serotonin receptor. Non-specific binding of this ligand is less than 5% of the total binding. |
| doi_str_mv | 10.1016/0014-2999(85)90093-7 |
| format | Article |
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125I) of SKF 83692 (2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol) produces a ligand of high specific activity. In the caudate nucleus of rat brain, this ligand binds to a site which discriminates between the active and inactive enantiomers of drugs selective for the D-1 receptor but which does not recognize drugs selective for the D-2 dopamine receptor or a serotonin receptor. Non-specific binding of this ligand is less than 5% of the total binding.</description><subject>2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine</subject><subject>Animals</subject><subject>Benzazepine enantiomers</subject><subject>Benzazepines - analogs & derivatives</subject><subject>Biological and medical sciences</subject><subject>Catecholaminergic system</subject><subject>Caudate Nucleus - metabolism</subject><subject>D-1 dopamine receptor</subject><subject>In Vitro Techniques</subject><subject>Iodine Radioisotopes</subject><subject>Ligands</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Neurotransmitters. Neurotransmission. Receptors</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Receptors, Dopamine - analysis</subject><subject>Receptors, Dopamine D1</subject><subject>SCH 23390</subject><subject>SKF 38393</subject><subject>SKF 83566</subject><subject>SKF 83692</subject><subject>Stereoisomerism</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFOGzEQhq0KlAbaN2ilPVSoPSy11-u1fUGKUgpISFzaszUZj8Fo403tDRJvz6aJcuQ0h_-bmV8fY18EvxRcdD85F23dWGu_G_XDcm5lrT-wuTDa1lyL5oTNj8hHdlbKM-dc2UbN2KyxUjTGzJldpCoOPiYYyVd9fITkq-gpjTG8xvRYjU9U_apF5YcNrGOiKhPSZhzyJ3YaoC_0-TDP2d_f13-Wt_X9w83dcnFfozTdWEuAloACkLdadRikh5XCrtWoggGBChrDfaPDVBmV5FIIrQSil4CrgPKcXezvbvLwb0tldOtYkPoeEg3b4nQntZG8m8B2D2IeSskU3CbHNeRXJ7jbGXM7HW6nwxnl_htzelr7eri_Xa3JH5cOiqb82yGHgtCHDAljOWKmba2xu-9Xe4wmFy-RsisYKSH5OBkbnR_i-z3eAOOLht4</recordid><startdate>19850731</startdate><enddate>19850731</enddate><creator>Sidhu, Anita</creator><creator>Kebabian, John W.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19850731</creationdate><title>An iodinated ligand identifying the D-1 dopamine receptor</title><author>Sidhu, Anita ; Kebabian, John W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-3aa4eaefaed9756cf3dab5c647c5f8a1c5a280d27f712c530311751ccd3acbfc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine</topic><topic>Animals</topic><topic>Benzazepine enantiomers</topic><topic>Benzazepines - analogs & derivatives</topic><topic>Biological and medical sciences</topic><topic>Catecholaminergic system</topic><topic>Caudate Nucleus - metabolism</topic><topic>D-1 dopamine receptor</topic><topic>In Vitro Techniques</topic><topic>Iodine Radioisotopes</topic><topic>Ligands</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Neurotransmitters. Neurotransmission. Receptors</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Receptors, Dopamine - analysis</topic><topic>Receptors, Dopamine D1</topic><topic>SCH 23390</topic><topic>SKF 38393</topic><topic>SKF 83566</topic><topic>SKF 83692</topic><topic>Stereoisomerism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sidhu, Anita</creatorcontrib><creatorcontrib>Kebabian, John W.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sidhu, Anita</au><au>Kebabian, John W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An iodinated ligand identifying the D-1 dopamine receptor</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1985-07-31</date><risdate>1985</risdate><volume>113</volume><issue>3</issue><spage>437</spage><epage>440</epage><pages>437-440</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>Iodination (with
125I) of SKF 83692 (2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol) produces a ligand of high specific activity. In the caudate nucleus of rat brain, this ligand binds to a site which discriminates between the active and inactive enantiomers of drugs selective for the D-1 receptor but which does not recognize drugs selective for the D-2 dopamine receptor or a serotonin receptor. Non-specific binding of this ligand is less than 5% of the total binding.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>2931288</pmid><doi>10.1016/0014-2999(85)90093-7</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-2999 |
| ispartof | European journal of pharmacology, 1985-07, Vol.113 (3), p.437-440 |
| issn | 0014-2999 1879-0712 |
| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine Animals Benzazepine enantiomers Benzazepines - analogs & derivatives Biological and medical sciences Catecholaminergic system Caudate Nucleus - metabolism D-1 dopamine receptor In Vitro Techniques Iodine Radioisotopes Ligands Male Medical sciences Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Rats Rats, Inbred Strains Receptors, Dopamine - analysis Receptors, Dopamine D1 SCH 23390 SKF 38393 SKF 83566 SKF 83692 Stereoisomerism |
| title | An iodinated ligand identifying the D-1 dopamine receptor |
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