An iodinated ligand identifying the D-1 dopamine receptor

Iodination (with 125I) of SKF 83692 (2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol) produces a ligand of high specific activity. In the caudate nucleus of rat brain, this ligand binds to a site which discriminates between the active and inactive enantiomers of drugs selective for the D-1...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of pharmacology 1985-07, Vol.113 (3), p.437-440
Hauptverfasser:	Sidhu, Anita, Kebabian, John W.
Format:	Artikel
Sprache:	eng
Schlagworte:	2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine Animals Benzazepine enantiomers Benzazepines - analogs & derivatives Biological and medical sciences Catecholaminergic system Caudate Nucleus - metabolism D-1 dopamine receptor In Vitro Techniques Iodine Radioisotopes Ligands Male Medical sciences Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Rats Rats, Inbred Strains Receptors, Dopamine - analysis Receptors, Dopamine D1 SCH 23390 SKF 38393 SKF 83566 SKF 83692 Stereoisomerism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Iodination (with 125I) of SKF 83692 (2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol) produces a ligand of high specific activity. In the caudate nucleus of rat brain, this ligand binds to a site which discriminates between the active and inactive enantiomers of drugs selective for the D-1 receptor but which does not recognize drugs selective for the D-2 dopamine receptor or a serotonin receptor. Non-specific binding of this ligand is less than 5% of the total binding.
ISSN:	0014-2999 1879-0712
DOI:	10.1016/0014-2999(85)90093-7