Low-dose aspirin in patients recovering from myocardial infarction. Evidence for a selective inhibition of thromboxane-related platelet function
The adequacy, selectivity and long-term persistence of inhibition in cyclooxygenase-dependent platelet function by a daily low-dose (0.45 mg kg−1 day−1) aspirin treatment have been evaluated in 15 patients after a recent (less than 17 days) acute myocardial infarction. Serum thromboxane (TX) B2, an...
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| Veröffentlicht in: | European heart journal 1985-05, Vol.6 (5), p.409-417 |
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| container_title | European heart journal |
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| creator | DE CATERINA, R. GIANNESSI, D. BERNINI, W. GAZZETTI, P. MICHELASSI, C. L'ABBATE, A. DONATO, L. PATRIGNANl, P. FlLABOZZl, P. PATRONO, C. |
| description | The adequacy, selectivity and long-term persistence of inhibition in cyclooxygenase-dependent platelet function by a daily low-dose (0.45 mg kg−1 day−1) aspirin treatment have been evaluated in 15 patients after a recent (less than 17 days) acute myocardial infarction. Serum thromboxane (TX) B2, an index of platelet TXA2 production, was decreased by 94–98% (P |
| doi_str_mv | 10.1093/oxfordjournals.eurheartj.a061879 |
| format | Article |
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Evidence for a selective inhibition of thromboxane-related platelet function</title><source>MEDLINE</source><source>Oxford University Press Journals Digital Archive Legacy</source><creator>DE CATERINA, R. ; GIANNESSI, D. ; BERNINI, W. ; GAZZETTI, P. ; MICHELASSI, C. ; L'ABBATE, A. ; DONATO, L. ; PATRIGNANl, P. ; FlLABOZZl, P. ; PATRONO, C.</creator><creatorcontrib>DE CATERINA, R. ; GIANNESSI, D. ; BERNINI, W. ; GAZZETTI, P. ; MICHELASSI, C. ; L'ABBATE, A. ; DONATO, L. ; PATRIGNANl, P. ; FlLABOZZl, P. ; PATRONO, C.</creatorcontrib><description>The adequacy, selectivity and long-term persistence of inhibition in cyclooxygenase-dependent platelet function by a daily low-dose (0.45 mg kg−1 day−1) aspirin treatment have been evaluated in 15 patients after a recent (less than 17 days) acute myocardial infarction. Serum thromboxane (TX) B2, an index of platelet TXA2 production, was decreased by 94–98% (P<0.001) by aspirin, while urinary excretion of 6-keto-prostaglandin Fla, as an index of extraplatelet cyclooxygenase activity, remained unchanged. Compared to placebo, aspirin induced a persistent increase in bleeding time (% difference 45.6±21.4, mean ± SD) and a decrease in platelet aggregation by ADP, epinephrine, collagen and arachidonic acid. No tendency towards an attenuation of the effects was apparent for the period of aspirin administration (4 weeks). Aspirin 0.45 mg kg−1 day−1 is adequate and selective in the long-term inhibition of TX-related platelet function in patients after acute myocardial infarction. The clinical effectiveness of such a regimen remains to be proven in clinical trials.</description><identifier>ISSN: 0195-668X</identifier><identifier>EISSN: 1522-9645</identifier><identifier>DOI: 10.1093/oxfordjournals.eurheartj.a061879</identifier><identifier>PMID: 3930246</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Adult ; Aged ; Aspirin ; Aspirin - administration & dosage ; Aspirin - therapeutic use ; Bleeding Time ; Blood Platelets - drug effects ; Blood Platelets - enzymology ; Blood Platelets - metabolism ; Cyclooxygenase Inhibitors ; Double-Blind Method ; Female ; Humans ; Male ; Middle Aged ; Myocardial Infarction - drug therapy ; platelet function ; prostacyclin ; Prostaglandin-Endoperoxide Synthases - metabolism ; thromboxane ; Thromboxane A2 - antagonists & inhibitors ; Thromboxane A2 - physiology ; Thromboxane B2 - antagonists & inhibitors ; Thromboxane B2 - biosynthesis</subject><ispartof>European heart journal, 1985-05, Vol.6 (5), p.409-417</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c364t-28a08f7e555b69914eef956defb59da192a4c8a99939b337e5d9b05c8b0102c73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3930246$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DE CATERINA, R.</creatorcontrib><creatorcontrib>GIANNESSI, D.</creatorcontrib><creatorcontrib>BERNINI, W.</creatorcontrib><creatorcontrib>GAZZETTI, P.</creatorcontrib><creatorcontrib>MICHELASSI, C.</creatorcontrib><creatorcontrib>L'ABBATE, A.</creatorcontrib><creatorcontrib>DONATO, L.</creatorcontrib><creatorcontrib>PATRIGNANl, P.</creatorcontrib><creatorcontrib>FlLABOZZl, P.</creatorcontrib><creatorcontrib>PATRONO, C.</creatorcontrib><title>Low-dose aspirin in patients recovering from myocardial infarction. Evidence for a selective inhibition of thromboxane-related platelet function</title><title>European heart journal</title><addtitle>Eur Heart J</addtitle><description>The adequacy, selectivity and long-term persistence of inhibition in cyclooxygenase-dependent platelet function by a daily low-dose (0.45 mg kg−1 day−1) aspirin treatment have been evaluated in 15 patients after a recent (less than 17 days) acute myocardial infarction. Serum thromboxane (TX) B2, an index of platelet TXA2 production, was decreased by 94–98% (P<0.001) by aspirin, while urinary excretion of 6-keto-prostaglandin Fla, as an index of extraplatelet cyclooxygenase activity, remained unchanged. Compared to placebo, aspirin induced a persistent increase in bleeding time (% difference 45.6±21.4, mean ± SD) and a decrease in platelet aggregation by ADP, epinephrine, collagen and arachidonic acid. No tendency towards an attenuation of the effects was apparent for the period of aspirin administration (4 weeks). Aspirin 0.45 mg kg−1 day−1 is adequate and selective in the long-term inhibition of TX-related platelet function in patients after acute myocardial infarction. The clinical effectiveness of such a regimen remains to be proven in clinical trials.</description><subject>Adult</subject><subject>Aged</subject><subject>Aspirin</subject><subject>Aspirin - administration & dosage</subject><subject>Aspirin - therapeutic use</subject><subject>Bleeding Time</subject><subject>Blood Platelets - drug effects</subject><subject>Blood Platelets - enzymology</subject><subject>Blood Platelets - metabolism</subject><subject>Cyclooxygenase Inhibitors</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - drug therapy</subject><subject>platelet function</subject><subject>prostacyclin</subject><subject>Prostaglandin-Endoperoxide Synthases - metabolism</subject><subject>thromboxane</subject><subject>Thromboxane A2 - antagonists & inhibitors</subject><subject>Thromboxane A2 - physiology</subject><subject>Thromboxane B2 - antagonists & inhibitors</subject><subject>Thromboxane B2 - biosynthesis</subject><issn>0195-668X</issn><issn>1522-9645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkdGK1DAUhoMo67j6CEKuxJvOJk2TNnfKsuvKDLiIwuJNSNMTJ2Pb1CQdZ9_CRzazMwwIgQP5P_6c8CH0npIlJZJd-b31odv6OYy6j0uYwwZ0SNulJoI2tXyGFpSXZSFFxZ-jBaGSF0I0Dy_Rqxi3hJBGUHGBLphkpKzEAv1d-z9F5yNgHScX3IjzmXRyMKaIAxi_g3z7E9vgBzw8eqND53SfMauDSc6PS3yzcx2MBnBeDmscoYec7CBDG9e6A4S9xWmTO1q_1yMUAXqdoMPTYfSQsJ3Hp7bX6IXNX4M3p3mJvt_efLu-K9ZfPn2-_rguDBNVKspGk8bWwDlvhZS0ArCSiw5sy2WnqSx1ZRotpWSyZSyDnWwJN01LKClNzS7Ru2PvFPzvGWJSg4sG-j5v5-eoasHqWsomgx-OoAk-xgBWTcENOjwqStRBivpfijpLUScpueLt6a25HaA7F5ws5Lw45i4m2J9jHX4pUbOaq7uHH2q9alb3919XqmH_APUvphg</recordid><startdate>198505</startdate><enddate>198505</enddate><creator>DE CATERINA, R.</creator><creator>GIANNESSI, D.</creator><creator>BERNINI, W.</creator><creator>GAZZETTI, P.</creator><creator>MICHELASSI, C.</creator><creator>L'ABBATE, A.</creator><creator>DONATO, L.</creator><creator>PATRIGNANl, P.</creator><creator>FlLABOZZl, P.</creator><creator>PATRONO, C.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198505</creationdate><title>Low-dose aspirin in patients recovering from myocardial infarction. Evidence for a selective inhibition of thromboxane-related platelet function</title><author>DE CATERINA, R. ; GIANNESSI, D. ; BERNINI, W. ; GAZZETTI, P. ; MICHELASSI, C. ; L'ABBATE, A. ; DONATO, L. ; PATRIGNANl, P. ; FlLABOZZl, P. ; PATRONO, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c364t-28a08f7e555b69914eef956defb59da192a4c8a99939b337e5d9b05c8b0102c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aspirin</topic><topic>Aspirin - administration & dosage</topic><topic>Aspirin - therapeutic use</topic><topic>Bleeding Time</topic><topic>Blood Platelets - drug effects</topic><topic>Blood Platelets - enzymology</topic><topic>Blood Platelets - metabolism</topic><topic>Cyclooxygenase Inhibitors</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myocardial Infarction - drug therapy</topic><topic>platelet function</topic><topic>prostacyclin</topic><topic>Prostaglandin-Endoperoxide Synthases - metabolism</topic><topic>thromboxane</topic><topic>Thromboxane A2 - antagonists & inhibitors</topic><topic>Thromboxane A2 - physiology</topic><topic>Thromboxane B2 - antagonists & inhibitors</topic><topic>Thromboxane B2 - biosynthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DE CATERINA, R.</creatorcontrib><creatorcontrib>GIANNESSI, D.</creatorcontrib><creatorcontrib>BERNINI, W.</creatorcontrib><creatorcontrib>GAZZETTI, P.</creatorcontrib><creatorcontrib>MICHELASSI, C.</creatorcontrib><creatorcontrib>L'ABBATE, A.</creatorcontrib><creatorcontrib>DONATO, L.</creatorcontrib><creatorcontrib>PATRIGNANl, P.</creatorcontrib><creatorcontrib>FlLABOZZl, P.</creatorcontrib><creatorcontrib>PATRONO, C.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DE CATERINA, R.</au><au>GIANNESSI, D.</au><au>BERNINI, W.</au><au>GAZZETTI, P.</au><au>MICHELASSI, C.</au><au>L'ABBATE, A.</au><au>DONATO, L.</au><au>PATRIGNANl, P.</au><au>FlLABOZZl, P.</au><au>PATRONO, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low-dose aspirin in patients recovering from myocardial infarction. Evidence for a selective inhibition of thromboxane-related platelet function</atitle><jtitle>European heart journal</jtitle><addtitle>Eur Heart J</addtitle><date>1985-05</date><risdate>1985</risdate><volume>6</volume><issue>5</issue><spage>409</spage><epage>417</epage><pages>409-417</pages><issn>0195-668X</issn><eissn>1522-9645</eissn><abstract>The adequacy, selectivity and long-term persistence of inhibition in cyclooxygenase-dependent platelet function by a daily low-dose (0.45 mg kg−1 day−1) aspirin treatment have been evaluated in 15 patients after a recent (less than 17 days) acute myocardial infarction. Serum thromboxane (TX) B2, an index of platelet TXA2 production, was decreased by 94–98% (P<0.001) by aspirin, while urinary excretion of 6-keto-prostaglandin Fla, as an index of extraplatelet cyclooxygenase activity, remained unchanged. Compared to placebo, aspirin induced a persistent increase in bleeding time (% difference 45.6±21.4, mean ± SD) and a decrease in platelet aggregation by ADP, epinephrine, collagen and arachidonic acid. No tendency towards an attenuation of the effects was apparent for the period of aspirin administration (4 weeks). Aspirin 0.45 mg kg−1 day−1 is adequate and selective in the long-term inhibition of TX-related platelet function in patients after acute myocardial infarction. The clinical effectiveness of such a regimen remains to be proven in clinical trials.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>3930246</pmid><doi>10.1093/oxfordjournals.eurheartj.a061879</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0195-668X |
| ispartof | European heart journal, 1985-05, Vol.6 (5), p.409-417 |
| issn | 0195-668X 1522-9645 |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy |
| subjects | Adult Aged Aspirin Aspirin - administration & dosage Aspirin - therapeutic use Bleeding Time Blood Platelets - drug effects Blood Platelets - enzymology Blood Platelets - metabolism Cyclooxygenase Inhibitors Double-Blind Method Female Humans Male Middle Aged Myocardial Infarction - drug therapy platelet function prostacyclin Prostaglandin-Endoperoxide Synthases - metabolism thromboxane Thromboxane A2 - antagonists & inhibitors Thromboxane A2 - physiology Thromboxane B2 - antagonists & inhibitors Thromboxane B2 - biosynthesis |
| title | Low-dose aspirin in patients recovering from myocardial infarction. Evidence for a selective inhibition of thromboxane-related platelet function |
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