Low-dose aspirin in patients recovering from myocardial infarction. Evidence for a selective inhibition of thromboxane-related platelet function

Low-dose aspirin in patients recovering from myocardial infarction. Evidence for a selective inhibition of thromboxane-related platelet function

The adequacy, selectivity and long-term persistence of inhibition in cyclooxygenase-dependent platelet function by a daily low-dose (0.45 mg kg−1 day−1) aspirin treatment have been evaluated in 15 patients after a recent (less than 17 days) acute myocardial infarction. Serum thromboxane (TX) B2, an...

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Veröffentlicht in:European heart journal 1985-05, Vol.6 (5), p.409-417
Hauptverfasser: DE CATERINA, R., GIANNESSI, D., BERNINI, W., GAZZETTI, P., MICHELASSI, C., L'ABBATE, A., DONATO, L., PATRIGNANl, P., FlLABOZZl, P., PATRONO, C.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Aspirin
Aspirin - administration & dosage
Aspirin - therapeutic use
Bleeding Time
Blood Platelets - drug effects
Blood Platelets - enzymology
Blood Platelets - metabolism
Cyclooxygenase Inhibitors
Double-Blind Method
Female
Humans
Male
Middle Aged
Myocardial Infarction - drug therapy
platelet function
prostacyclin
Prostaglandin-Endoperoxide Synthases - metabolism
thromboxane
Thromboxane A2 - antagonists & inhibitors
Thromboxane A2 - physiology
Thromboxane B2 - antagonists & inhibitors
Thromboxane B2 - biosynthesis
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Zusammenfassung:The adequacy, selectivity and long-term persistence of inhibition in cyclooxygenase-dependent platelet function by a daily low-dose (0.45 mg kg−1 day−1) aspirin treatment have been evaluated in 15 patients after a recent (less than 17 days) acute myocardial infarction. Serum thromboxane (TX) B2, an index of platelet TXA2 production, was decreased by 94–98% (P
ISSN:0195-668X
1522-9645
DOI:10.1093/oxfordjournals.eurheartj.a061879