Verapamil induced increment of oxygen extraction in the arteriosclerotic limb

The acute effect of intravenously administered verapamil (0.08 mg·kg-1body weight, mean dose 5.1 ± 0.7 mg) on oxygen exchange and arterial blood flow (measured electromagnetically) of the lower limb was studied during reconstructive arterial surgery in 17 patients with obliterative arterial disease...

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Veröffentlicht in:	Cardiovascular research 1985-09, Vol.19 (9), p.567-569
Hauptverfasser:	BAGGER, JENS P, MATHAR, RALPH, PAULSEN, PETER K, GORMSEN, JÖRGEN, OLSEN, KIRSTEN H
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biological and medical sciences blood flow Blood Pressure - drug effects Cardiovascular system Female Humans Intermittent Claudication - drug therapy Ischemia - physiopathology Leg lower limb ischaemia Male Medical sciences Middle Aged Oxygen - physiology oxygen extraction Pharmacology. Drug treatments Vasodilator agents. Cerebral vasodilators verapamil Verapamil - therapeutic use
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Zusammenfassung:	The acute effect of intravenously administered verapamil (0.08 mg·kg-1body weight, mean dose 5.1 ± 0.7 mg) on oxygen exchange and arterial blood flow (measured electromagnetically) of the lower limb was studied during reconstructive arterial surgery in 17 patients with obliterative arterial disease of the lower limbs. Verapamil increased oxygen extraction in the diseased leg by 12% (from a median value of 28.3 to 31.6 ml·litre-1, p
ISSN:	0008-6363 1755-3245
DOI:	10.1093/cvr/19.9.567