Assembly of glial intermediate filament protein is initiated in the centriolar region

Assembly of glial intermediate filament protein is initiated in the centriolar region

Assembly of glial intermediate filament protein (GFP) into intermediate filaments (IF) was first detected by immunofluorescence in the perinuclear region of astrocytes differentiating in colony cultures before the rest of the cytoplasm was labeled. Double labeling with antisera specific for centriol...

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Veröffentlicht in:Brain research 1985-10, Vol.345 (2), p.322-326
Hauptverfasser: Kalnins, V.I., Subrahmanyan, L., Fedoroff, S.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
astrocyte
Astrocytes - physiology
Biological and medical sciences
centriole
Centrioles - physiology
Cytoskeleton
Fluorescent Antibody Technique
Fundamental and applied biological sciences. Psychology
Glial Fibrillary Acidic Protein - metabolism
intermediate filament assembly
Intermediate Filaments
Isolated neuron and nerve. Neuroglia
Mice
Mice, Inbred DBA
Vertebrates: nervous system and sense organs
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Zusammenfassung:Assembly of glial intermediate filament protein (GFP) into intermediate filaments (IF) was first detected by immunofluorescence in the perinuclear region of astrocytes differentiating in colony cultures before the rest of the cytoplasm was labeled. Double labeling with antisera specific for centrioles indicated that this site corresponds to the centriolar region. These studies suggest that the centriolar region plays an important role in the assembly of some types of IF as well as microtubules.
ISSN:0006-8993
1872-6240
DOI:10.1016/0006-8993(85)91009-1