Activation of washed chicken thrombocytes by 1- O-hexadecyl/octadecyl-2-acetyl- sn-glycero-3-phosphorylcholine (platelet-activating factor)

1. 1. Washed, [ 3H]serotonin-labeled chicken thrombocytes aggregated and secreted [ 3H]serotonin when stimulated in vitro with platelet-activating factor (PAF), collagen and calcium ionophore A23187. 2. 2. The effective dose causing a 25% secretion of [ 3H]serotonin (ED 25) from washed chicken throm...

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Veröffentlicht in:	Comparative biochemistry and physiology. A, Comparative physiology Comparative physiology, 1985, Vol.82 (1), p.145-151
1. Verfasser:	Cox, Charles P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood coagulation. Blood cells Blood Platelets - metabolism Calcimycin - pharmacology Calcium - pharmacology Cations, Divalent Chickens Collagen - pharmacology Egtazic Acid - pharmacology Fundamental and applied biological sciences. Psychology Kinetics Magnesium - pharmacology Molecular and cellular biology Platelet Platelet Activating Factor - physiology Platelet Aggregation - drug effects Serotonin - blood
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Beschreibung
Zusammenfassung:	1. 1. Washed, [ 3H]serotonin-labeled chicken thrombocytes aggregated and secreted [ 3H]serotonin when stimulated in vitro with platelet-activating factor (PAF), collagen and calcium ionophore A23187. 2. 2. The effective dose causing a 25% secretion of [ 3H]serotonin (ED 25) from washed chicken thrombocytes was 10 −8 M for PAF, 5 × 10 −8 M for collagen and 3 × 10 −7 M for A23187. 3. 3. Chicken thrombocyte activation by PAF required Ca 2+ and appeared to be mediated through a specific receptor for PAF.
ISSN:	0300-9629
DOI:	10.1016/0300-9629(85)90719-4