Antiulcer Activity of Dehydroabietic Acid Derivatives

Derivatives of dehydroabietic acid (1) having a hydrophilic moiety (such as amino, carbamoyl, carbamoyloxy, ureido, sulfamoyl, or sulfo) at positions 12 and/or 18 of the dehydroabietane nucleus were prepared and tested for antiulcer activity by means of antisecretory and antipepsin assays in rats. A...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1985/04/25, Vol.33(4), pp.1472-1487
Hauptverfasser:	WADA, HIROSHI, KODATO, SHINICHI, KAWAMORI, MASATOSHI, MORIKAWA, TAMIO, NAKAI, HIDEO, TAKEDA, MIKIO, SAITO, SEIICHI, ONODA, YUICHI, TAMAKI, HAJIME
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldosterone - pharmacology Alicyclic compounds, terpenoids, prostaglandins, steroids Animals Anti-Ulcer Agents - chemical synthesis Chemical Phenomena Chemistry Diterpenes - chemical synthesis Diterpenes - pharmacology Diterpenes, Abietane Exact sciences and technology Gastric Juice - metabolism Male Organic chemistry Preparations and properties Rats Rats, Inbred Strains structure-activity relationship Terpenoids
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Zusammenfassung:	Derivatives of dehydroabietic acid (1) having a hydrophilic moiety (such as amino, carbamoyl, carbamoyloxy, ureido, sulfamoyl, or sulfo) at positions 12 and/or 18 of the dehydroabietane nucleus were prepared and tested for antiulcer activity by means of antisecretory and antipepsin assays in rats. Among these compounds, the salts of 12-sulfodehydroabietic acid (62, 63, and 64) were found to exhibit remarkably high antipepsin activity without aldosterone-like activity.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.33.1472