Visualization of Damaged Brain Tissue After Ischemic Stroke with Cobalt-55 Positron Emission Tomography

In animal experiments, the radionuclide 55Co2+ has been shown to accumulate in degenerating cerebral tissue similar to Ca2+. The potential role of 55Co2+ for in vivo brain PET imaging was investigated in four patients after ischemic stroke. PET showed uptake of 55Co2+ in damaged brain tissue irrespe...

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Veröffentlicht in:	The Journal of nuclear medicine (1978) 1994-03, Vol.35 (3), p.456-460
Hauptverfasser:	Jansen, H.M.L, Pruim, J, Vliet, A.M. v.d, Paans, A.M.J, Hew, J.M, Franssen, E.J.F, de Jong, B.M, Kosterink, J.G.W, Haaxma, R, Korf, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Blood-Brain Barrier Brain - diagnostic imaging Brain - pathology Brain Ischemia - diagnosis Brain Ischemia - diagnostic imaging Cobalt Radioisotopes Female Humans Magnetic Resonance Imaging Male Middle Aged Tomography, Emission-Computed - methods Tomography, X-Ray Computed
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Zusammenfassung:	In animal experiments, the radionuclide 55Co2+ has been shown to accumulate in degenerating cerebral tissue similar to Ca2+. The potential role of 55Co2+ for in vivo brain PET imaging was investigated in four patients after ischemic stroke. PET showed uptake of 55Co2+ in damaged brain tissue irrespective of blood-brain barrier integrity, as affirmed by CT and MRI. Our preliminary results indicate that 55CoCl2 may prove to be a useful and relatively inexpensive PET radiopharmaceutical for visualization of degenerative processes in brain tissue.
ISSN:	0161-5505 1535-5667