How B and T cells talk to each other

The B cells of the immune system, which secrete antibodies against foreign antigens, are fully specific and effective only after maturation in lymph nodes and other lymphoid tissues. Immunocompetent T cells play a crucial part in this process, but the molecular details of the way in which the two ce...

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Veröffentlicht in:	Nature (London) 1994-02, Vol.367 (6462), p.425-428
Hauptverfasser:	Clark, Edward A, Ledbetter, Jeffrey A
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of the immune response. Humoral and cellular immunity Animals Antigens, CD - physiology B-Lymphocytes - physiology Biological and medical sciences Cell Adhesion Molecules - physiology Cell Communication - physiology Cell interactions Cellular biology Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immune system Immunity (Disease) Immunobiology Lymph nodes Lymphocyte Activation - physiology Medical research Receptors, Antigen, B-Cell - physiology T-Lymphocytes - physiology
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Beschreibung
Zusammenfassung:	The B cells of the immune system, which secrete antibodies against foreign antigens, are fully specific and effective only after maturation in lymph nodes and other lymphoid tissues. Immunocompetent T cells play a crucial part in this process, but the molecular details of the way in which the two cell types interact have only recently become apparent.
ISSN:	0028-0836 1476-4687
DOI:	10.1038/367425a0