The Rate of Healing of Duodenal Ulcers during Omeprazole Treatment

We have studied the rate of healing of duodenal ulcers in 44 patients treated with omeprazole, 40 mg once daily for 4 weeks, with or without an 80-mg loading dose on day 1. Fourteen patients (32%) had healed by the end of the 1st week's treatment and a further 27 after a further week (giving a...

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Veröffentlicht in:	Scandinavian journal of gastroenterology 1985-01, Vol.20 (6), p.691-695
Hauptverfasser:	Naesdal, J., Lind, T., Bergsåker-aspöy, J., Bernklev, T., Farup, P. G., Gillberg, R., Halvorsen, L., Kilander, A., Offergaard, S., Walan, A., Lloyd-Davies, K. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Anti-Ulcer Agents - therapeutic use ATPase inhibitor Benzimidazole Benzimidazoles - administration & dosage Benzimidazoles - therapeutic use Biological and medical sciences clinical trial Clinical Trials as Topic Digestive system duodenal ulcer Duodenal Ulcer - drug therapy Female Gastric Acid - metabolism gastric acid secretion healing Humans inhibition Male Medical sciences Middle Aged Omeprazole peptic ulcer Pharmacology. Drug treatments substituted Time Factors
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Zusammenfassung:	We have studied the rate of healing of duodenal ulcers in 44 patients treated with omeprazole, 40 mg once daily for 4 weeks, with or without an 80-mg loading dose on day 1. Fourteen patients (32%) had healed by the end of the 1st week's treatment and a further 27 after a further week (giving a cumulative total of 93%). All patients (100%) had healed by the end of the treatment period. There was no significant difference in healing rate between the two treatment groups. Ulcer symptoms were relieved rapidly, and the drug was well tolerated.
ISSN:	0036-5521 1502-7708
DOI:	10.3109/00365528509089196