Towards preparative-scale, biocatalytic alkene reductions

Towards preparative-scale, biocatalytic alkene reductions

Simple strategies for using alkene reductase enzymes to produce gram-scale quantities of both (R)- and (S)-citronellal have been developed. The methodology is easily accessible to non-specialist laboratories, allowing alkene reductases to be added to the toolbox of routine synthetic transformations.

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2010-12, Vol.46 (45), p.8558-8560
Hauptverfasser: Bougioukou, Despina J, Walton, Adam Z, Stewart, Jon D
Format: Artikel
Sprache:eng
Schlagworte:
Aldehydes - chemistry
Aldehydes - metabolism
Alkenes - chemistry
Alkenes - metabolism
Animals
Biocatalysis
Cattle
Escherichia coli - enzymology
Monoterpenes - chemistry
Monoterpenes - metabolism
Oxidation-Reduction
Oxidoreductases - biosynthesis
Oxidoreductases - genetics
Oxidoreductases - metabolism
Pichia - enzymology
Stereoisomerism
Substrate Specificity
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Beschreibung
Zusammenfassung:Simple strategies for using alkene reductase enzymes to produce gram-scale quantities of both (R)- and (S)-citronellal have been developed. The methodology is easily accessible to non-specialist laboratories, allowing alkene reductases to be added to the toolbox of routine synthetic transformations.
ISSN:1359-7345
1364-548X
DOI:10.1039/c0cc03119d