Dose response in the treatment of breast cancer

We present evidence that drugs that are effective in causing regression of metastatic breast cancer in a dose-dependent fashion also cause a dose-dependent reduction of cytokines produced by the immune system. This may be an important factor in the occasional induction of a complete remission.

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Bibliographische Detailangaben
Veröffentlicht in:	The Lancet (British edition) 1994-02, Vol.343 (8894), p.402-404
Hauptverfasser:	Stewart, H.M., Retsky, M.W., Tsai, S.C.J., Verma, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences Bone Marrow Transplantation Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - immunology Breast Neoplasms - secondary Breast Neoplasms - therapy Chemotherapy Chemotherapy, Adjuvant Cytokines - drug effects Dose-Response Relationship, Drug Drug therapy Female Humans Immune system Immunity (Disease) Immunosuppression Medical research Medical sciences Pharmacology. Drug treatments Pregnanes - therapeutic use Remission Induction
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Beschreibung
Zusammenfassung:	We present evidence that drugs that are effective in causing regression of metastatic breast cancer in a dose-dependent fashion also cause a dose-dependent reduction of cytokines produced by the immune system. This may be an important factor in the occasional induction of a complete remission.
ISSN:	0140-6736 1474-547X
DOI:	10.1016/S0140-6736(94)91229-7