Loss of The Normal NF1 Allele from the Bone Marrow of Children with Type 1 Neurofibromatosis and Malignant Myeloid Disorders
Proteins encoded by the RAS family of proto-oncogenes regulate cellular growth and differentiation by cycling between an active state in which they are bound to guanosine triphosphate (Ras-GTP) and an inactive state in which they are bound to guanosine diphosphate (Ras-GDP) 1 , 2 . During the develo...
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Veröffentlicht in: | The New England journal of medicine 1994-03, Vol.330 (9), p.597-601 |
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Sprache: | eng |
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Zusammenfassung: | Proteins encoded by the RAS family of proto-oncogenes regulate cellular growth and differentiation by cycling between an active state in which they are bound to guanosine triphosphate (Ras-GTP) and an inactive state in which they are bound to guanosine diphosphate (Ras-GDP)
1
,
2
. During the development of cancer in humans, these genes commonly acquire activating point mutations that perturb the biochemical activity of Ras proteins by elevating the level of Ras-GTP
3
. Yeast and mammalian GTPase-activating proteins normally regulate the biologic activity of Ras proteins by accelerating the hydrolysis of GTP. Because it is Ras-GTP that actively transduces signals, GTPase-activating . . . |
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ISSN: | 0028-4793 1533-4406 |
DOI: | 10.1056/NEJM199403033300903 |