Loss of The Normal NF1 Allele from the Bone Marrow of Children with Type 1 Neurofibromatosis and Malignant Myeloid Disorders

Proteins encoded by the RAS family of proto-oncogenes regulate cellular growth and differentiation by cycling between an active state in which they are bound to guanosine triphosphate (Ras-GTP) and an inactive state in which they are bound to guanosine diphosphate (Ras-GDP) 1 , 2 . During the develo...

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Veröffentlicht in:The New England journal of medicine 1994-03, Vol.330 (9), p.597-601
Hauptverfasser: Shannon, Kevin M, O'Connell, Peter, Martin, George A, Paderanga, Dorothy, Olson, Kristin, Dinndorf, Patricia, McCormick, Frank
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Sprache:eng
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Zusammenfassung:Proteins encoded by the RAS family of proto-oncogenes regulate cellular growth and differentiation by cycling between an active state in which they are bound to guanosine triphosphate (Ras-GTP) and an inactive state in which they are bound to guanosine diphosphate (Ras-GDP) 1 , 2 . During the development of cancer in humans, these genes commonly acquire activating point mutations that perturb the biochemical activity of Ras proteins by elevating the level of Ras-GTP 3 . Yeast and mammalian GTPase-activating proteins normally regulate the biologic activity of Ras proteins by accelerating the hydrolysis of GTP. Because it is Ras-GTP that actively transduces signals, GTPase-activating . . .
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM199403033300903