Hexokinase Activities in Normal, Hyperplastic and Cancerous Epidermis of Mice

IT is usually postulated that carcinogenic hydrocarbons convert normal cells into cancerous cells by a somatic mutation. Although we know much about the metabolic reactions of established tumours, little is known about the biochemistry of the onset of the tumorous state. One difficulty is the lack of samples large enough for standard biochemical procedures: transformation to malignancy can occur in a single cell.