Hyperinsulinemia in Normotensive Offspring of Hypertensive Parents

Hyperinsulinemia and insulin resistance have been extensively reported in adult patients with essential hypertension. The aim of this study was to examine serum glucose and insulin levels both in the fasting state and after 0.25 g/kg IV glucose and to relate those findings to the status of intracell...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 1994-01, Vol.23 (1 Suppl I), p.I-12-I-15
Hauptverfasser:	Grunfeld, Beatriz, Balzareti, Marta, Romo, Myriam, Gimenez, Marisa, Gutman, Raul
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Glucose - metabolism Blood Pressure Body Mass Index Cardiology. Vascular system Child Cholesterol - blood Cholesterol, HDL - blood Cholesterol, LDL - blood Clinical manifestations. Epidemiology. Investigative techniques. Etiology Fasting Female Humans Hyperinsulinism - blood Hyperinsulinism - genetics Hyperinsulinism - physiopathology Hypertension - genetics Hypertension - physiopathology Insulin - blood Male Medical sciences Nuclear Family Triglycerides - blood
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Zusammenfassung:	Hyperinsulinemia and insulin resistance have been extensively reported in adult patients with essential hypertension. The aim of this study was to examine serum glucose and insulin levels both in the fasting state and after 0.25 g/kg IV glucose and to relate those findings to the status of intracellular Na and red blood cell Na-Li countertransport in a population of 21 normolipemic normotensive offspring of hypertensive parents (N-EH) and 13 control children without a history of parental essential hypertension or diabetes mellitus matched for age, body mass index, and pubertal stage. Offspring of hypertensive parents presented significantly higher serum insulin levels both after an overnight fast (17.4±1.6 versus 11.6±1.6 fiU/mh in control [mean±SEM], P
ISSN:	0194-911X 1524-4563
DOI:	10.1161/01.hyp.23.1_suppl.i12