Unexpected High Incidence of Tumours in Thymectomized Mice treated with Anti-lymphocytic Globulin and Mycobacterium leprae

During an attempt to transmit human leprosy ( Mycobacterium leprae ) to mice, polyoma-type tumours arose in all mice thymectomized as adults and treated with anti-lymphocytic globulin (ALS I g G).

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Bibliographische Detailangaben
Veröffentlicht in:	Nature (London) 1969-03, Vol.221 (5185), p.1033-1036
Hauptverfasser:	GAUGAS, J. M, HARVEY, JENNIFER J, CHESTERMAN, F. C, HIRSCH, M. S, GILCHRIST, C, REES, R. J. W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma, Pleomorphic Animals Antilymphocyte Serum - therapeutic use Bone Neoplasms Female Fibrosarcoma Humanities and Social Sciences Immunization, Passive Immunosuppressive Agents - therapeutic use Leiomyosarcoma Leprosy Lymphocytes - immunology Mammary Neoplasms, Experimental - pathology Mice multidisciplinary Mycobacterium leprae - pathogenicity Neoplasms, Experimental - etiology Neoplasms, Experimental - pathology Neutralization Tests Osteosarcoma Sarcoma Science Science (multidisciplinary) Thymectomy Uterine Neoplasms
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Beschreibung
Zusammenfassung:	During an attempt to transmit human leprosy ( Mycobacterium leprae ) to mice, polyoma-type tumours arose in all mice thymectomized as adults and treated with anti-lymphocytic globulin (ALS I g G).
ISSN:	0028-0836 1476-4687
DOI:	10.1038/2211033a0