Ciliary Trafficking: CEP290 Guards a Gated Community

A recent study reveals that the large coiled-coil protein CEP290 is an integral component of the transition zone between the cell body and the cilium and functions as a gatekeeper to regulate trafficking of ciliary proteins.

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Bibliographische Detailangaben
Veröffentlicht in:	Current biology 2010-11, Vol.20 (21), p.R928-R931
Hauptverfasser:	Betleja, Ewelina, Cole, Douglas G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Chlamydomonas - genetics Chlamydomonas - metabolism Chlamydomonas - ultrastructure Cilia - metabolism Cilia - ultrastructure Membrane Proteins - genetics Membrane Proteins - metabolism Membrane Proteins - physiology Plant Proteins - genetics Plant Proteins - metabolism Plant Proteins - physiology Protein Transport - genetics
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Beschreibung
Zusammenfassung:	A recent study reveals that the large coiled-coil protein CEP290 is an integral component of the transition zone between the cell body and the cilium and functions as a gatekeeper to regulate trafficking of ciliary proteins.
ISSN:	0960-9822 1879-0445
DOI:	10.1016/j.cub.2010.09.058