Primary structure of mouse secretogranin III and its absence from deficient mice

The rat brain- and pituitary-specific 1B1075 mRNA encodes a chromogranin/secretogranin-like protein, called secretogranin III (SgIII), that is a component of intracellular dense core vesicles. In order to study the function of this gene product in a mouse model system, we have isolated the murine ho...

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Veröffentlicht in:Journal of molecular neuroscience 1993-12, Vol.4 (4), p.225-233
Hauptverfasser: Dopazo, A, Lovenberg, T W, Danielson, P E, Ottiger, H P, Sutcliffe, J G
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Sprache:eng
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Zusammenfassung:The rat brain- and pituitary-specific 1B1075 mRNA encodes a chromogranin/secretogranin-like protein, called secretogranin III (SgIII), that is a component of intracellular dense core vesicles. In order to study the function of this gene product in a mouse model system, we have isolated the murine homolog of the rat 1B1075 mRNA. This mRNA contains 2163 bp encoding a putative protein of 421 amino acids. Cleavage of the strong putative signal sequence would yield a mature protein of 51 kDa. The sequence of the encoded murine protein preserves the structural features that suggest SgIII is a member of the granin family, and allowed us to recognize and correct errors in our published rat sequence.
ISSN:0895-8696
1559-1166
DOI:10.1007/bf02821554