Macromolecular crowding and molecular recognition

Macromolecular crowding and molecular recognition

The effects of macromolecular crowding upon macromolecular associations in solution, and upon binding of a macromolecular ligand to a surface site, ar ereviewed. It is demonstrated, by means of two examples, that crowding may lead to significant alterations of biochemical or biological recognition p...

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Veröffentlicht in:JMR. Journal of molecular recognition 1993-12, Vol.6 (4), p.211-214
1. Verfasser: Minton, Allen P.
Format: Artikel
Sprache:eng
Schlagworte:
Binding Sites
Binding, Competitive
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
In Vitro Techniques
Interactions. Associations
Intermolecular phenomena
Ligands
Macromolecular Substances
Models, Biological
Models, Chemical
Molecular biophysics
Receptors, Virus - physiology
Solutions
Thermodynamics
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Beschreibung
Zusammenfassung:The effects of macromolecular crowding upon macromolecular associations in solution, and upon binding of a macromolecular ligand to a surface site, ar ereviewed. It is demonstrated, by means of two examples, that crowding may lead to significant alterations of biochemical or biological recognition processes at the molecular level.
ISSN:0952-3499
1099-1352
DOI:10.1002/jmr.300060410