In Vitro Effect of Some Chemicals on Histaminopexy II: Quantification and Potentiation of Histaminopexy

Optimum conditions for histaminopexic determinations were defined resulting in complete dialysis in 18hr. at 25°. Complexation of histamine with the dialysis membrane was found to be significant and dependent upon histamine concentration. Due to lack of predictability, individual corrections for thi...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1969-01, Vol.58 (1), p.97-99
Hauptverfasser:	Cohen, M.L., Nieforth, K.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites di- and thymoquinone effect-histamine binding Dialysis Flavonoids gamma-Globulins Histamine Histamine dihydrochloride Histamine dihydrochloride, radioactive—dialysis rate Histaminopexy-in vitro determination Membrane binding-labeled histamine Protein Binding Protein binding-labeled histamine Quercetin Quercetin, di- and thymoquinone effect—histamine binding Quinones radioactive-dialysis rate Radioisotopes
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Zusammenfassung:	Optimum conditions for histaminopexic determinations were defined resulting in complete dialysis in 18hr. at 25°. Complexation of histamine with the dialysis membrane was found to be significant and dependent upon histamine concentration. Due to lack of predictability, individual corrections for this phenomenon were made for each determination. The interaction of gamma globulin was found to follow the law of mass action and was enhanced by quercetin.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600580120