Transferrin and HLA: Spontaneous Abortion, Neural Tube Defects, and Natural Selection

We report evidence that transferrin C3, a gene present in 9 to 10 per cent of whites, is associated with recurrent spontaneous abortion (P = 0.001) and that maternal transferrin genotype has an effect on the transmission ratio of the common transferrin genes (C1, C2, and C3) from heterozygous father...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 1985-10, Vol.313 (15), p.925-932
Hauptverfasser:	Weitkamp, Lowell R, Schacter, Bernice Z
Format:	Artikel
Sprache:	eng
Schlagworte:	Abortion Abortion, Habitual - genetics Alleles Animal reproduction Antigens Applied sciences Biological and medical sciences Chromosome 3 Chromosome 6 Chromosomes Couples Defects Diseases of mother, fetus and pregnancy Exact sciences and technology Female Fetuses Gene Frequency Genes Genetic Markers Genetics Genotype Gynecology. Andrology. Obstetrics Histocompatibility antigen HLA HLA Antigens - genetics HLA-A Antigens HLA-B Antigens Humans Infant, Newborn Male Mating Mating types Medical sciences Models, Genetic Natural selection Neural tube defects Neural Tube Defects - genetics Other techniques and industries Ovum Pregnancy Pregnancy. Fetus. Placenta Selection, Genetic Sperm Spermatozoa Transferrin - genetics Transferrins
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	We report evidence that transferrin C3, a gene present in 9 to 10 per cent of whites, is associated with recurrent spontaneous abortion (P = 0.001) and that maternal transferrin genotype has an effect on the transmission ratio of the common transferrin genes (C1, C2, and C3) from heterozygous fathers to normal offspring (P
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJM198510103131505