Genetic control of polyketide biosynthesis in the genus Streptomyces

The genetic control of polyketide metabolite biosynthesis in Streptomyces sp. producing actinorhodin, daunorubicin, erythromycin, spiramycin, tetracenomycin and tylosin is reviewed. Several examples of positively-acting transcriptional regulators of polyketide metabolism are known, including some tw...

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Veröffentlicht in:	Antonie van Leeuwenhoek 1993-01, Vol.64 (2), p.165-176
Hauptverfasser:	Hutchinson, C R, Decker, H, Madduri, K, Otten, S L, Tang, L
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Anti-Bacterial Agents - biosynthesis Bacterial Proteins - biosynthesis Consensus Sequence Daunorubicin - biosynthesis Furans - chemical synthesis Genes, Bacterial Lactones - chemical synthesis Molecular Sequence Data Multigene Family Operon Restriction Mapping Sequence Homology, Amino Acid Streptomyces - genetics Streptomyces - metabolism
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Zusammenfassung:	The genetic control of polyketide metabolite biosynthesis in Streptomyces sp. producing actinorhodin, daunorubicin, erythromycin, spiramycin, tetracenomycin and tylosin is reviewed. Several examples of positively-acting transcriptional regulators of polyketide metabolism are known, including some two-component sensor kinase-response regulator systems. Translational and posttranslational control mechanisms are only briefly mentioned since very little is known about either of these processes. Examples of how enzyme levels and substrate supply affect polyketide metabolism also are discussed.
ISSN:	0003-6072
DOI:	10.1007/BF00873025