Selective expression of histone genes in mouse-human hybrid cells
Mouse-human hybrid cells preferentially segregating mouse chromosomes contain predominantly human histone mRNAs and synthesize human histone proteins. In contrast, hybrids segregating human chromosomes contain both human and murine histone mRNAs, yet synthesize only mouse histone proteins. These res...
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| Veröffentlicht in: | Experimental cell research 1985-08, Vol.159 (2), p.280-286 |
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| container_title | Experimental cell research |
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| creator | Marashi, Farhad Croce, Carlo M. Stein, Janet L. Stein, Gary S. |
| description | Mouse-human hybrid cells preferentially segregating mouse chromosomes contain predominantly human histone mRNAs and synthesize human histone proteins. In contrast, hybrids segregating human chromosomes contain both human and murine histone mRNAs, yet synthesize only mouse histone proteins. These results suggest transcriptional control of histone gene expression in hybrids segregating mouse chromosomes and post-transcriptional regulation in hybrids segregating human chromosomes. |
| doi_str_mv | 10.1016/S0014-4827(85)80002-1 |
| format | Article |
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In contrast, hybrids segregating human chromosomes contain both human and murine histone mRNAs, yet synthesize only mouse histone proteins. These results suggest transcriptional control of histone gene expression in hybrids segregating mouse chromosomes and post-transcriptional regulation in hybrids segregating human chromosomes.</description><subject>Animal cells</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell cultures. Hybridization. Fusion</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation</subject><subject>Histones - genetics</subject><subject>Humans</subject><subject>Hybrid Cells</subject><subject>Mice</subject><subject>Molecular and cellular biology</subject><subject>Protein Processing, Post-Translational</subject><subject>RNA, Messenger - analysis</subject><issn>0014-4827</issn><issn>1090-2422</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LI0EQhhtx0Rj9CcIcRPQwu_3dPScJYVeFwB5cz81MdY1pmY_YnYj---2YkKungqqnql4eQi4Z_cko07-eKGWylJabG6tuLaWUl-yITBitaMkl58dkckBOyVlKr5mxlukTciIpr7hhEzJ7wg5hHd6xwI9VxJTCOBRjWyxDWo8DFi84YCrCUPTjJmG53PT1UCw_mxh8Adh16Zz8aOsu4cW-Tsnzn9__5g_l4u_943y2KEEIsy49-oYKzYQHSWWlDSiPohKUg6ptblQIYDxXynveQNuAkSA8g0ZboYQWU3K9u7uK49sG09r1IW0T1APmaM5obiqd4SlROxDimFLE1q1i6Ov46Rh1W3XuS53benFWuS91juW9y_2DTdOjP2ztXeX51X5eJ6i7NtYDhHTArJJamipjdzsMs4z3gNElCDgA-hCzaefH8E2Q_57linE</recordid><startdate>198508</startdate><enddate>198508</enddate><creator>Marashi, Farhad</creator><creator>Croce, Carlo M.</creator><creator>Stein, Janet L.</creator><creator>Stein, Gary S.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198508</creationdate><title>Selective expression of histone genes in mouse-human hybrid cells</title><author>Marashi, Farhad ; Croce, Carlo M. ; Stein, Janet L. ; Stein, Gary S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-dedb03613dc404967c5de39302c5a84969ecc7d255dd2bcfbc74c3d1cb6835363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Animal cells</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell cultures. 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| ispartof | Experimental cell research, 1985-08, Vol.159 (2), p.280-286 |
| issn | 0014-4827 1090-2422 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animal cells Animals Biological and medical sciences Cell cultures. Hybridization. Fusion Fundamental and applied biological sciences. Psychology Gene Expression Regulation Histones - genetics Humans Hybrid Cells Mice Molecular and cellular biology Protein Processing, Post-Translational RNA, Messenger - analysis |
| title | Selective expression of histone genes in mouse-human hybrid cells |
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