Selective expression of histone genes in mouse-human hybrid cells

Mouse-human hybrid cells preferentially segregating mouse chromosomes contain predominantly human histone mRNAs and synthesize human histone proteins. In contrast, hybrids segregating human chromosomes contain both human and murine histone mRNAs, yet synthesize only mouse histone proteins. These res...

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Veröffentlicht in:	Experimental cell research 1985-08, Vol.159 (2), p.280-286
Hauptverfasser:	Marashi, Farhad, Croce, Carlo M., Stein, Janet L., Stein, Gary S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal cells Animals Biological and medical sciences Cell cultures. Hybridization. Fusion Fundamental and applied biological sciences. Psychology Gene Expression Regulation Histones - genetics Humans Hybrid Cells Mice Molecular and cellular biology Protein Processing, Post-Translational RNA, Messenger - analysis
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Zusammenfassung:	Mouse-human hybrid cells preferentially segregating mouse chromosomes contain predominantly human histone mRNAs and synthesize human histone proteins. In contrast, hybrids segregating human chromosomes contain both human and murine histone mRNAs, yet synthesize only mouse histone proteins. These results suggest transcriptional control of histone gene expression in hybrids segregating mouse chromosomes and post-transcriptional regulation in hybrids segregating human chromosomes.
ISSN:	0014-4827 1090-2422
DOI:	10.1016/S0014-4827(85)80002-1