Phosphorothioates in pre-tRNAs can change the specificities of RNAses P or reduce the cleavage efficiencies

Several phosphorothioate-madified E coli and yeast pre-tRNAs were synthesized. If this modification included the phosphodiester at the RNase P cleavage site, two different effects were observed. With some pre-tRNAs the RNase P cleavage efficiency was severely reduced, whereas with other pre-tRNAs a...

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Veröffentlicht in:	Biochimie 1993, Vol.75 (11), p.955-962
Hauptverfasser:	Kahle, D, Küst, B, Krupp, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Base Composition Base Sequence Biological and medical sciences catalytic RNA Endoribonucleases - metabolism Escherichia coli - genetics Escherichia coli Proteins Fundamental and applied biological sciences. Psychology modified RNA Molecular Sequence Data Mutation Nucleic acids Ribonuclease P ribozyme RNA Precursors - chemistry RNA Precursors - genetics RNA Precursors - metabolism RNA processing RNA, Catalytic - metabolism Rna, ribonucleoproteins RNA, Transfer - chemistry RNA, Transfer - genetics RNA, Transfer - metabolism RNA, Transfer, Amino Acyl - chemistry RNA, Transfer, Amino Acyl - genetics RNA, Transfer, Amino Acyl - metabolism Thionucleosides - chemistry Thionucleosides - metabolism Transcription, Genetic Yeasts - genetics
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